| Tag | Content |
|---|
| CPLM ID | CPLM-007211 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rab GDP-dissociation inhibitor |
Protein Synonyms/Alias | Rab GDI; Secretory pathway GDP dissociation inhibitor |
Gene Name | GDI1 |
Gene Synonyms/Alias | SEC19; YER136W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 67 | FKQNPISKEERESKF | ubiquitination | [1] | | 406 | EPREDGSKDNIYLSR | ubiquitination | [1] | | 429 | ESMTDDVKDIYFRVT | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4. Plays an essential role in the yeast secretory pathway. |
Sequence Annotation | REGION 106 112 Interaction with YPT1.
REGION 234 259 Interaction with YPT1. |
Keyword | 3D-structure; Complete proteome; Cytoplasm; GTPase activation; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 451 AA |
Protein Sequence | MDQETIDTDY DVIVLGTGIT ECILSGLLSV DGKKVLHIDK QDHYGGEAAS VTLSQLYEKF 60
KQNPISKEER ESKFGKDRDW NVDLIPKFLM ANGELTNILI HTDVTRYVDF KQVSGSYVFK 120
QGKIYKVPAN EIEAISSPLM GIFEKRRMKK FLEWISSYKE DDLSTHQGLD LDKNTMDEVY 180
YKFGLGNSTK EFIGHAMALW TNDDYLQQPA RPSFERILLY CQSVARYGKS PYLYPMYGLG 240
ELPQGFARLS AIYGGTYMLD TPIDEVLYKK DTGKFEGVKT KLGTFKAPLV IADPTYFPEK 300
CKSTGQRVIR AICILNHPVP NTSNADSLQI IIPQSQLGRK SDIYVAIVSD AHNVCSKGHY 360
LAIISTIIET DKPHIELEPA FKLLGPIEEK FMGIAELFEP REDGSKDNIY LSRSYDASSH 420
FESMTDDVKD IYFRVTGHPL VLKQRQEQEK Q 451 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0005093; F:Rab GDP-dissociation inhibitor activity; IDA:SGD. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0016192; P:vesicle-mediated transport; IMP:SGD. |
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