CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028009
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cortactin 
Protein Synonyms/Alias
 LD29964p 
Gene Name
 Cortactin 
Gene Synonyms/Alias
 CG3637; Dmel_CG3637 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
88AGYGYGGKFGVEKDRacetylation[1]
125YSDGFGGKFGVQEDRacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 559 AA 
Protein Sequence
MWKASAGHQI QATSAASAED DDWETDPDFV NDVSEQEQRW GSKTIDGSGR TAGTIDMDKL 60
REETEQADLD KKKQLLKDQN AGYGYGGKFG VEKDRMDKSA VGHDYQGKVG KHASQKDYSD 120
GFGGKFGVQE DRKDKSAVGW DHVEKVEKHA SQKDYATGFG GKFGVQSDRV DKSAVGWDHI 180
EKVEKHESQK DYSKGFGGKF GVQEDRKDKS AVGWDHKEAP QKHASQVDHK VKPVIEGAKP 240
SNLRAKFENL AKNSEEESRK RAEEQKRLRE AKDKRDREEA AKKTVAENTP RTSTEAPPPK 300
GSRAAIQTGR TGGIGNAISA FNQMQSPVSE TPPARKEPII IPKAQPVKIE LEAKEEPTAS 360
TTSAAVAPTP TVVPAREPET APVAKAAAPP PDVVPQIEVE TVDTPPRSEP QSPVYVPTPQ 420
PEVHAQVQVQ PEPQPQADPE PVVEEEPLYQ NQAEIKAASP LPPTNGTVSE AVAPSGTATV 480
PEEAIYANSD NLADYLEDTG IHAIALYDYQ AADDDEISFD PDDVITHIEK IDDGWWRGLC 540
KNRYGLFPAN YVQVVGQNS 559 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0030027; C:lamellipodium; IEA:InterPro.
 GO:0043234; C:protein complex; IPI:FlyBase.
 GO:0001726; C:ruffle; IEA:InterPro.
 GO:0070864; C:sperm individualization complex; IDA:FlyBase.
 GO:0070064; F:proline-rich region binding; IGI:FlyBase.
 GO:0007298; P:border follicle cell migration; IMP:FlyBase.
 GO:0007301; P:female germline ring canal formation; IMP:FlyBase.
 GO:0048260; P:positive regulation of receptor-mediated endocytosis; IGI:FlyBase.
 GO:0008360; P:regulation of cell shape; IMP:FlyBase. 
Interpro
 IPR015503; Cortactin.
 IPR003134; Hs1_Cortactin.
 IPR000108; p67phox.
 IPR001452; SH3_domain. 
Pfam
 PF02218; HS1_rep
 PF00018; SH3_1 
SMART
 SM00326; SH3 
PROSITE
 PS51090; CORTACTIN
 PS50002; SH3 
PRINTS
 PR00499; P67PHOX.
 PR00452; SH3DOMAIN.