UniProt Accession

 DYR_DROME; P17719; A4V302; Q9VEU4 

Genbank Protein ID

 U06861; AE014297; AE014297 

Genbank Nucleotide ID

 AAA19051.1; AAF55324.1; ABI31175.1 

Protein Name

 Dihydrofolate reductase 

Protein Synonyms/Alias

  

Gene Name

 Dhfr 

Gene Synonyms/Alias

 CG14887 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
31	WRIKSELKYFSRTTK	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 By interacting with vestigial (vg), may control genes involved in DNA replication. 

Sequence Annotation

 DOMAIN 3 180 DHFR.
 NP_BIND 15 21 NADP (By similarity).
 NP_BIND 53 55 NADP (By similarity).
 NP_BIND 75 77 NADP (By similarity).
 NP_BIND 113 120 NADP (By similarity).
 REGION 29 34 Substrate binding (By similarity).
 BINDING 9 9 NADP; via amide nitrogen and carbonyl
 BINDING 69 69 Substrate (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; DNA replication; NADP; One-carbon metabolism; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0004146; F:dihydrofolate reductase activity; IDA:FlyBase.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
 GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
 GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR012259; DHFR.
 IPR024072; DHFR-like_dom.
 IPR017925; DHFR_CS.
 IPR001796; DHFR_dom. 

Pfam

 PF00186; DHFR_1 

SMART

  

PROSITE

 PS00075; DHFR_1
 PS51330; DHFR_2 

PRINTS

 PR00070; DHFR.