UniProt Accession

 HYLS1_HUMAN; Q96M11; B3KXI8; Q96BX9 

Genbank Protein ID

 AK057477; AK127394; AP000842; BC015047 

Genbank Nucleotide ID

 BAB71503.1; BAG54500.1; AAH15047.1 

Protein Name

 Hydrolethalus syndrome protein 1 

Protein Synonyms/Alias

  

Gene Name

 HYLS1 

Gene Synonyms/Alias

 HLS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	IQYDPYSKASVAPGK	ubiquitination	[1, 2]
144	NVQFQEDKESSFDVS	ubiquitination	[1]
199	PKSFILPKLDQLSRN	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Ciliopathy; Complete proteome; Cytoplasm; Disease mutation; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA. 

Interpro

 IPR026227; HYLS1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR02098; HYLETHALUSS1.