CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016092
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gap junction gamma-2 protein 
Protein Synonyms/Alias
 Connexin-47; Cx47; Gap junction alpha-12 protein 
Gene Name
 Gjc2 
Gene Synonyms/Alias
 Gja12 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
186KGGGGDGKTVVTPGPubiquitination[1]
419AQEQLATKPRVGSEKubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems (By similarity). 
Sequence Annotation
 MOD_RES 372 372 Phosphoserine (By similarity).  
Keyword
 Cell junction; Cell membrane; Complete proteome; Gap junction; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 440 AA 
Protein Sequence
MTNMSWSFLT RLLEEIHNHS TFVGKVWLTV LVVFRIVLTA VGGESIYSDE QSKFTCNTRQ 60
PGCDNVCYDA FAPLSHVRFW VFQIVVISTP SVMYLGYAVH RLARASEQER RRALRRRPGP 120
RRLPRAQLPP PPPGWPDTTD LGEAEPILAL EEDEDEEPGA PEGPGEDTEE ERTEDVAAKG 180
GGGDGKTVVT PGPAGQHDGR RRIQREGLMR VYVAQLVVRA AFEVAFLVGQ YLLYGFEVPP 240
FFACSRQPCP HVVDCFVSRP TEKTVFLLVM YVVSCLCLLL NLCEMAHLGL GSAQDAVRGR 300
RGASAAGPGP APRPPPCAFP AAAAGLACPP DYSLVVRAAE RARAHDQNLA NLALQALRDG 360
AAVAAVSADR DSPPCSGLNA TSRGPPRAGG PASGTGSATS GGTVGEQGRS GAQEQLATKP 420
RVGSEKGSTG SRDGKATVWI 440 
Gene Ontology
 GO:0005922; C:connexon complex; IEA:InterPro.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043209; C:myelin sheath; IEA:Compara.
 GO:0005243; F:gap junction channel activity; IEA:Compara.
 GO:0007267; P:cell-cell signaling; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara. 
Interpro
 IPR000500; Connexin.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 
Pfam
 PF00029; Connexin
 PF10582; Connexin_CCC 
SMART
 SM00037; CNX
 SM01089; Connexin_CCC 
PROSITE
 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 
PRINTS
 PR00206; CONNEXIN.