UniProt Accession

 LMNB1_RAT; P70615 

Genbank Protein ID

 U72353 

Genbank Nucleotide ID

 AAB09600.1 

Protein Name

 Lamin-B1 

Protein Synonyms/Alias

  

Gene Name

 Lmnb1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
157	ATALGDKKSLEGDLE	ubiquitination	[1]
182	ASLSAAKKQLADETL	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (By similarity). 

Sequence Annotation

 REGION 2 34 Head.
 REGION 35 386 Rod.
 REGION 35 69 Coil 1A.
 REGION 70 81 Linker 1.
 REGION 82 215 Coil 1B.
 REGION 216 243 Linker 2.
 REGION 244 386 Coil 2.
 REGION 387 587 Tail.
 MOTIF 415 420 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 3 3 Phosphothreonine (By similarity).
 MOD_RES 5 5 Phosphothreonine (By similarity).
 MOD_RES 16 16 Phosphoserine (By similarity).
 MOD_RES 20 20 Phosphothreonine (By similarity).
 MOD_RES 23 23 Phosphoserine (By similarity).
 MOD_RES 157 157 N6-acetyllysine (By similarity).
 MOD_RES 271 271 N6-acetyllysine (By similarity).
 MOD_RES 375 375 Phosphoserine (By similarity).
 MOD_RES 391 391 Phosphoserine (By similarity).
 MOD_RES 393 393 Phosphoserine (By similarity).
 MOD_RES 483 483 N6-acetyllysine (By similarity).
 MOD_RES 576 576 Phosphothreonine (By similarity).
 MOD_RES 584 584 Cysteine methyl ester (By similarity).
 LIPID 584 584 S-farnesyl cysteine (By similarity).
 DISULFID 317 317 Interchain (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; Disulfide bond; Intermediate filament; Lipoprotein; Membrane; Methylation; Nucleus; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 587 AA 

Protein Sequence

Gene Ontology

 GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
 GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
 GO:0016363; C:nuclear matrix; IDA:RGD.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR001322; Lamin_tail_dom. 

Pfam

 PF00038; Filament
 PF00932; LTD 

SMART

  

PROSITE

 PS00226; IF 

PRINTS