CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026073
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucyl-tRNA synthetase 
Protein Synonyms/Alias
 Protein Lars 
Gene Name
 Lars 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
9AERKGTAKVDFLKKIacetylation[1]
280VLDPYPSKLSGLKGKacetylation[1]
343MSYQGFTKHNGVVPVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1178 AA 
Protein Sequence
MAERKGTAKV DFLKKIEKEV QQKWEAEKVF EVSASSLEKQ KQSSKGKYFV TFPYPYMNGR 60
LHLGHTFSLS KCEFAVGYQR LKGKSCLFPF GLHCTGMPIK ACADKLKREI ELYGCPPDFP 120
EEEEEEEESS AKPGDIVMKD KAKGKKSKAA AKAGSSKYQW NIMKSLGLSD EDIAKFSEAE 180
HWLDYFPPLA VQDLKKIGLK VDWRRSFITT DVNPYYDSFV RWQFLTLRER NKIKFGKRYT 240
IYSPKDGQPC MDHDRQTGEG VGPQEYTLVK LKVLDPYPSK LSGLKGKNIF LVAATLRPET 300
MFGQTNCWVR PDMKYIGFET ANGDIFICTQ RAARNMSYQG FTKHNGVVPV VKELMGEEIL 360
GASLSAPLTC YKVIYVLPML TIKEDKGTGV VTSVPSDSPD DFAALRDLKK KQALRAKYAV 420
RDDMVLPFEP VPVLEIPGIG NLPAVTVCDE LKIQSQNDRE KLAEAKEKLY LRGFYDGVML 480
VDGFKGQKIQ HVKKTIQKNM IDAGDALIYM EPEKQVVSRS ADECVVALCD QWYLDYGDEN 540
WKKQTFQCLK NMETFCEESR KNFEASLDWL QEHACSRTYG LGTRLPWDEQ WLIESLSDST 600
IYMAFYTVAH LLQGGDLQGQ AESPLGIRPQ QMTRDVWDYV FFKDAPFPKT QIPKEKLDQL 660
KQEFEFWYPV DLRASGKDLI PNHLSYYIYN HVAMWPEQSD KWPVSVRANG HLLLNSEKMS 720
KSTGNFLTLS QAVDKFSADG MRLALADAGD TVEDANFVEA MADAGILRLY TWVEWVKEML 780
ANCSSLRSGP ANSFNDRVFA SEMNAGIIKT DQNYEKMMFK EALKTGFFEF QAAKDKYREL 840
ATEGMHRELV FRFIEVQTIL LTPFCPHLCE HIWTLLGKPD SIMHASWPVA GPVDESLIRS 900
SQYLMEVAHD LRLRLKNYMT PAKGKKTDKQ PVQRPSHCTI YVAKNYPVWQ HITLTTLRSH 960
FEANNGKLPD NKVIACELGS LPELKKYMKK VMPFVAMIKE NMEKKGPRVL DLELEFDEQA 1020
VLMENIVYLT NSLELEHIDV KFASEAEDKV REECCPGKPL NVFRTEPGVP VSLVNPQPSS 1080
GHFSTKIDIR QGDSCESIIR RLTKMDRGIK DLSKVKLMRF DDPLLGPRRV PVLGREQNEK 1140
TLISENAIFH VDLVSKKVHL TENGLRADIG DTIVYLVH 1178 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004823; F:leucine-tRNA ligase activity; IEA:InterPro.
 GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
 GO:0006450; P:regulation of translational fidelity; IEA:GOC. 
Interpro
 IPR001412; aa-tRNA-synth_I_CS.
 IPR002300; aa-tRNA-synth_Ia.
 IPR004493; Leu-tRNA-synth_Ia_arc/euk.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR009080; tRNAsynth_1a_anticodon-bd.
 IPR013155; V/L/I-tRNA-synth_anticodon-bd.
 IPR009008; Val/Leu/Ile-tRNA-synth_edit. 
Pfam
 PF08264; Anticodon_1
 PF00133; tRNA-synt_1 
SMART
  
PROSITE
 PS00178; AA_TRNA_LIGASE_I 
PRINTS