| Tag | Content |
|---|
| CPLM ID | CPLM-005582 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | MAP/microtubule affinity-regulating kinase 3 |
Protein Synonyms/Alias | C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Par-1a; Serine/threonine-protein kinase p78 |
Gene Name | MARK3 |
Gene Synonyms/Alias | CTAK1; EMK2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 317 | GHEEDELKPFVEPEL | ubiquitination | [1] | | 741 | SGTSIAFKNIASKIA | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. |
Sequence Annotation | DOMAIN 56 307 Protein kinase.
DOMAIN 326 365 UBA.
DOMAIN 704 753 KA1.
NP_BIND 62 70 ATP (By similarity).
ACT_SITE 178 178 Proton acceptor (By similarity).
BINDING 85 85 ATP (By similarity).
MOD_RES 42 42 Phosphoserine.
MOD_RES 211 211 Phosphothreonine; by LKB1.
MOD_RES 383 383 Phosphoserine.
MOD_RES 400 400 Phosphoserine.
MOD_RES 469 469 Phosphoserine.
MOD_RES 549 549 Phosphothreonine.
MOD_RES 564 564 Phosphothreonine; by PKC/PRKCZ (By
MOD_RES 598 598 Phosphoserine.
MOD_RES 643 643 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 753 AA |
Protein Sequence | MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 60
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120
VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QIVSAVQYCH QKRIVHRDLK 180
AENLLLDADM NIKIADFGFS NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240
VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 300
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 360
YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVF SSQKQRRYSD 420
HAGPAIPSVV AYPKRSQTST ADSDLKEDGI SSRKSSGSAV GGKGIAPASP MLGNASNPNK 480
ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS 540
THSISSAATP DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 600
STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN KEAKPRSLRF 660
TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHAENL VQWEMEVCKL 720
PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL 753 |
Gene Ontology | GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |