CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024345
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Focadhesin 
Protein Synonyms/Alias
  
Gene Name
 Focad 
Gene Synonyms/Alias
 Kiaa1797 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
122REGQSGEKDIQDIYSubiquitination[1]
390SLVEVLQKERHGDDSubiquitination[1]
577APSLSVGKELQWEKLubiquitination[1]
583GKELQWEKLIAKAASubiquitination[1]
587QWEKLIAKAASIRDIubiquitination[1]
796GIYHSALKGGVRSDQubiquitination[1]
1774AKSKDLLKATLLSLRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Potential tumor suppressor in gliomas. 
Sequence Annotation
 MOD_RES 816 816 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Cell junction; Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1798 AA 
Protein Sequence
MSDDIKKRFD FPNSLIQSQA VGHLIAAVLK EHGVSEKIHQ STNQTAALNL LWEKCCSDHV 60
VVRTACSEGL VALVAQGHAE FSYVLNGILN LTPSARNMSG LIKALMKLLQ MQALREGQSG 120
EKDIQDIYSI RNPPQPLITV LEHRPDCWPL LLQQLTAFFQ QCPERSEASC VQIMAPFLWY 180
LYCEPSQLEE YAKLRLSLLK VLLQPRGVCE EAQLSVREQS TLQLCCSMLP CLQMKDLMQT 240
TEMMLFVEEV YLSLLRHPGF WKSQLTQLTL QLLCICEVSL KITGECSSLI HLLERSVELL 300
GEDFPVELVI IGIALLLLQM PASQQKPLLN LALKLLSLTE GQKIPKASLL LLVPLLQILS 360
STALEDCLAM GEEGPSRQQL ALSLVEVLQK ERHGDDSHTI SCRLAFPVSS MYGSIFTAWR 420
ILDVIGEESA TSDWLATVES LLSATTVIPP HVFLLLAYLL VEDVGQNLQQ ILRVTTQLAQ 480
ADSSQVPNLI PVLMFKLGRP LDPVSYNHIL YTLPTLGVHK VCVGQILRVI QLLGTTPRLR 540
AVTLRLLTSL WEKQDRVYPE LQRFMAVSDA PSLSVGKELQ WEKLIAKAAS IRDICKQRPY 600
QHGADMLAAI SQVLNECTKP DQATPAALVL QGLHALCQAE VVCIRSTWNA LSPKLSCDMR 660
PLILKTLSEL FSLVPSLTVN TVEYENFKVQ VLSFLWTHTQ NKNPTVASAA YKSLSHFSAG 720
EHTILHLPEK IRPEMPVPGE LDEEESVDLS IPGACFLRLL TITAPSVLPA LEEFFTSLVR 780
QEMVNMPRGI YHSALKGGVR SDQGKTVAGI PNFILKTYET NKQPGLKPGL AGGMLFCYDL 840
AMYQSKDGKP LNRLMASRGR SFKQTTLALI HEVHVQLSEW HRAIFLPQAW LAYMTRAYHA 900
ILQGRIAELE LQLQHGKEGP EEVQYKRSTA WLWVRDMLTD EITKTAAKES PVVKANALLA 960
LSSLAVVVSK HEASLCSDSD GVLEIQPNFL PVKEWVSMVL NTLLVIVDSH YHPSGQLFTC 1020
FYHKSYSGEN TASAIARSAA ATALSLLVPV FIISCKEKVE EILNMLTARL PGKPSADESQ 1080
AVQIHMGLAL GMFLSRLCEE KLSDMSGQQM NLLLMKSLDA LESCCFDPSL EYNTGCILGV 1140
GLALSLMSHS SHTESRVHVA ASLRKLSTYL DESGSQSRTF QEVLVYTLSC VCTSAFSAGI 1200
IEAAEAEDIM SKLQLLVENN QQTSGFALAL GNLVYGLSVC GHGKAEDLGN RLRPSWIKVV 1260
LTEGAPTMLC LAALHGLVAL VGSDVDVMQL KSEAIQNTHF QARLNEVIRT LTEVISVSGV 1320
IGLQSNAIWL LGHLHLSTLS SNQSRTSVPT DYSYLPEGSF IRAAIGFFIT GGKKGPEAVP 1380
PSLLKVVMKP IATVGESYQY PPANLAALLS PLMRLNFGEE IQQLCLEIAV TQAPSSQSAA 1440
SLLGLWVMPP LIHGLSLNIK KYLLVSMPLW AKHVSDEQIQ GFVENLMVEV FKTASQPCHP 1500
EMCLSALQGL SQAMKLPSPS HHLWSLLCDA TGRIFDLLPN RIRRNDLELY ISIAKCLSEM 1560
TDEGVNQVSQ ITKDNIEKAA FVKLYLVSQG RLPLMSLTDL LTAAMQHPEK ETLAWMILHS 1620
LYQARIVNHA NTGVLKRLEW LLELMGYVRN IAYQSAPIQN VAPEEALDFL MLIFAAAVVA 1680
WADHEAPLLL GLSASWLPWH QQNGPGGPAA ALLGRSPMHR VTVQEVLTQL PRSMLLLLQK 1740
EPWKEQTQKF IDWLLSIMEI PNKAFAAKSK DLLKATLLSL RVLPEFKKKA VWTRAYGW 1798 
Gene Ontology
 GO:0005925; C:focal adhesion; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR016024; ARM-type_fold.
 IPR021392; DUF3028.
 IPR022542; DUF3730. 
Pfam
 PF11229; DUF3028
 PF12530; DUF3730 
SMART
  
PROSITE
  
PRINTS