CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031982
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ56564, highly similar to Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1219QTMGWGEKAIEIRSVubiquitination[1]
1238LDGVFMHKRAQRLKFubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1279 AA 
Protein Sequence
MLQALQLRTG FFCFRVLVAL SPCALHDSGR LTTGSFNVVR DEEEEIKLEI NMLKKYSHHR 60
NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG 120
LAHLHIHHVI HRDVKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 180
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP PRLKSKKWSK 240
KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI QLKDHIDRTR KKRGEKDETE 300
YEYSGSEEEE EEVPEQEGEP SSIVNVPGES TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ 360
LREQEEYKRQ LLAERQKRIE QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE 420
LERRRKEEEE RRRAEEEKRR VEREQEYIRR QLEEEQRHLE VLQQQLLQEQ AMLLHDHRRP 480
HPQHSQQPPP PQQERSKPSF HAPEPKAHYE PADRAREVQW SHLASLKNNV SPVSRSHSFS 540
DPSPKFAHHH LRSQDPCPPS RREVLSQSSD SKSEAPDPTQ KAWSRSDSDE VPPRVPVRTT 600
SRSPVLSRRD SPLQGSGQQN SQAGQRNSTS SIEPRLLWER VEKLVPRPGS GSSSGSSNSG 660
SQPGSHPGSQ SGSGERFRVR SSSKSEGSPS QRLENAVKKP EDKKEVFRPL KPAGEVDLTA 720
LAKELRAVED VRPPHKVTDY SSSSEESGTT DEEDDDVEQE GADESTSGPE DTRAASSLNL 780
SNGETESVKT MIVHDDVESE PAMTPSKEGT LIVRQSTVDQ KRASHHESNG FAGRIHLLPD 840
LLQQSHSSST SSTSSSPSSS QPTPTMSPQT PQDKLTANET QSASSTLQKH KSSSSFTPFI 900
DPRLLQISPS SGTTVTSVVG FSCDGMRPEA IRQDPTRKGS VVNVNPTNTR PQSDTPEIRK 960
YKKRFNSEIL CAALWGVNLL VGTESGLMLL DRSGQGKVYP LINRRRFQQM DVLEGLNVLV 1020
TISGKKDKLR VYYLSWLRNK ILHNDPEVEK KQGWTTVGDL EGCVHYKVVK YERIKFLVIA 1080
LKSSVEVYAW APKPYHKFMA FKSFGELVHK PLLVDLTVEE GQRLKVIHGS CAGFHAVDVD 1140
SGSVYDIYLP THIQCSIKPH AIIILPNTDG MELLVCYEDE GVYVNTYGRI TKDVVLQWGE 1200
MPTSVAYIRS NQTMGWGEKA IEIRSVETGH LDGVFMHKRA QRLKFLCERN DKVFFASVRS 1260
GGSSQVYFMT LGRTSLLSW 1279 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0005083; F:small GTPase regulator activity; IEA:InterPro. 
Interpro
 IPR001180; Citron.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00780; CNH
 PF00069; Pkinase 
SMART
 SM00036; CNH
 SM00220; S_TKc 
PROSITE
 PS50219; CNH
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS