CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014253
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Syntaxin-binding protein 3 
Protein Synonyms/Alias
 MUNC-18-3; Mammalian homolog of Unc-18c; Munc-18c; Protein unc-18 homolog 3; Unc18-3; Protein unc-18 homolog C; Unc-18C 
Gene Name
 Stxbp3 
Gene Synonyms/Alias
 Stxbp3a; Unc18c 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
67TVIENIYKNREPVRQubiquitination[1]
86YFISPTPKSVDCFLRubiquitination[1]
220KKLEDYYKIDEKGLIubiquitination[1]
224DYYKIDEKGLIKGKTubiquitination[1]
309EEIPKLMKEISSTKKubiquitination[1]
321TKKATEGKTSLSALTubiquitination[1]
332SALTQLMKKMPHFRKubiquitination[1]
359EDCMNKFKLNIEKLCubiquitination[1]
364KFKLNIEKLCKTEQDubiquitination[1]
384DAEGQRVKDSMLVLLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. 
Sequence Annotation
 REGION 1 255 Mediates interaction with DOC2B.
 MOD_RES 198 198 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 592 AA 
Protein Sequence
MAPPVSERGL KSVVWRKIKT AVFDDCRKEG EWKIMLLDEF TTKLLSSCCK MTDLLEEGIT 60
VIENIYKNRE PVRQMKALYF ISPTPKSVDC FLRDFGSKSE KKYKAAYIYF TDFCPDSLFN 120
KIKASCSKSI RRCKEINISF IPQESQVYTL DVPDAFYYCY SPDPSNASRK EVVMEAMAEQ 180
IVTVCATLDE NPGVRYKSKP LDNASKLAQL VEKKLEDYYK IDEKGLIKGK TQSQLLIIDR 240
GFDPVSTVLH ELTFQAMAYD LLPIENDTYK YKTDGKEKEA VLEEDDDLWV RVRHRHIAVV 300
LEEIPKLMKE ISSTKKATEG KTSLSALTQL MKKMPHFRKQ ISKQVVHLNL AEDCMNKFKL 360
NIEKLCKTEQ DLALGTDAEG QRVKDSMLVL LPVLLNKNHD NCDKIRAVLL YIFGINGTTE 420
ENLDRLIHNV KIEDDSDMIR NWSHLGVPIV PPSQQAKPLR KDRSAEETFQ LSRWTPFIKD 480
IMEDAIDNRL DSKEWPYCSR CPAVWNGSGA VSARQKPRTN YLELDRKNGS RLIIFVIGGI 540
TYSEMRCAYE VSQAHKSCEV IIGSTHILTP RKLLDDIKML NKSKDKVSFK DE 592 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0019905; F:syntaxin binding; IDA:MGI.
 GO:0007420; P:brain development; IMP:MGI.
 GO:0006887; P:exocytosis; IMP:MGI.
 GO:0015758; P:glucose transport; IDA:MGI.
 GO:0030073; P:insulin secretion; IMP:MGI.
 GO:0022615; P:protein to membrane docking; IMP:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0032868; P:response to insulin stimulus; IMP:MGI.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. 
Interpro
 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 
Pfam
 PF00995; Sec1 
SMART
  
PROSITE
  
PRINTS