UniProt Accession

 TMM97_HUMAN; Q5BJF2; B4DS02; Q07823 

Genbank Protein ID

 L19183; AK299511; BC091504 

Genbank Nucleotide ID

 AAA16188.1; BAG61464.1; AAH91504.1 

Protein Name

 Transmembrane protein 97 

Protein Synonyms/Alias

 Protein MAC30 

Gene Name

 TMEM97 

Gene Synonyms/Alias

 MAC30 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	VEFRNLLKWYAKEFK	ubiquitination	[1, 2, 3]
52	NLLKWYAKEFKDPLL	ubiquitination	[1, 3]
55	KWYAKEFKDPLLQEP	ubiquitination	[1, 3]
94	AFLKGSCKWIRTPAI	ubiquitination	[2]
130	FSKASGFKGQRPETL	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Plays a role as a regulator of cellular cholesterol homeostasis. 

Sequence Annotation

  

Keyword

 Cell membrane; Complete proteome; Endoplasmic reticulum; Lysosome; Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 176 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
 GO:0042632; P:cholesterol homeostasis; IDA:UniProtKB.
 GO:0001558; P:regulation of cell growth; NAS:UniProtKB. 

Interpro

 IPR016964; Transmembrane_6/97. 

Pfam

 PF10914; DUF2781 

SMART

  

PROSITE

  

PRINTS