UniProt Accession

 PP14B_RAT; Q8K3F3 

Genbank Protein ID

 AY122323 

Genbank Nucleotide ID

 AAM89292.1 

Protein Name

 Protein phosphatase 1 regulatory subunit 14B 

Protein Synonyms/Alias

 Phosphatase holoenzyme inhibitor 1; PHI-1; Ubiquitous PKC-potentiated PP1 inhibitor 

Gene Name

 Ppp1r14b 

Gene Synonyms/Alias

 Phi1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
59	RQGKVTVKYDRKELR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 32 32 Phosphoserine (By similarity).
 MOD_RES 57 57 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0019212; F:phosphatase inhibitor activity; IDA:RGD.
 GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
 GO:0008599; F:protein phosphatase type 1 regulator activity; IDA:RGD.
 GO:0042325; P:regulation of phosphorylation; IEA:InterPro. 

Interpro

 IPR008025; PP1_inhibitor. 

Pfam

 PF05361; PP1_inhibitor 

SMART

  

PROSITE

  

PRINTS