UniProt Accession

 COX17_MOUSE; P56394 

Genbank Protein ID

 AA168035; BC048668 

Genbank Nucleotide ID

 AAH48668.1 

Protein Name

 Cytochrome c oxidase copper chaperone 

Protein Synonyms/Alias

  

Gene Name

 Cox17 

Gene Synonyms/Alias

 Cox17a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
18	PPEAQEKKPLKPCCA	acetylation	[1, 2]
21	AQEKKPLKPCCACPE	acetylation	[1]
30	CCACPETKKARDACI	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity). 

Sequence Annotation

 METAL 23 23 Copper (By similarity).
 METAL 24 24 Copper (By similarity).
 DISULFID 26 55 By similarity.
 DISULFID 36 45 By similarity.  

Keyword

 Chaperone; Complete proteome; Copper; Disulfide bond; Metal-binding; Mitochondrion; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 63 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0016531; F:copper chaperone activity; IEA:InterPro.
 GO:0006825; P:copper ion transport; IEA:InterPro. 

Interpro

 IPR009069; Cys_alpha_HP_mot_SF.
 IPR007745; Cyt_c_oxidase_Cu-chaperone. 

Pfam

 PF05051; COX17 

SMART

  

PROSITE

  

PRINTS