| Tag | Content |
|---|
| CPLM ID | CPLM-007147 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Long-chain-fatty-acid--CoA ligase 2 |
Protein Synonyms/Alias | Fatty acid activator 2; Long-chain acyl-CoA synthetase 2 |
Gene Name | FAA2 |
Gene Synonyms/Alias | FAM1; YER015W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 226 | SNMYHVLKMVPDMKF | ubiquitination | [1] | | 259 | NESLLPVKCNSLNEK | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Preferentially acts on C9:0-C13:0 fatty acids although C7:0-C17:0 fatty acids are tolerated. |
Sequence Annotation | |
Keyword | ATP-binding; Complete proteome; Cytoplasm; Fatty acid metabolism; Ligase; Lipid metabolism; Magnesium; Mitochondrion; Nucleotide-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 744 AA |
Protein Sequence | MAAPDYALTD LIESDPRFES LKTRLAGYTK GSDEYIEELY SQLPLTSYPR YKTFLKKQAV 60
AISNPDNEAG FSSIYRSSLS SENLVSCVDK NLRTAYDHFM FSARRWPQRD CLGSRPIDKA 120
TGTWEETFRF ESYSTVSKRC HNIGSGILSL VNTKRKRPLE ANDFVVAILS HNNPEWILTD 180
LACQAYSLTN TALYETLGPN TSEYILNLTE APILIFAKSN MYHVLKMVPD MKFVNTLVCM 240
DELTHDELRM LNESLLPVKC NSLNEKITFF SLEQVEQVGC FNKIPAIPPT PDSLYTISFT 300
SGTTGLPKGV EMSHRNIASG IAFAFSTFRI PPDKRNQQLY DMCFLPLAHI FERMVIAYDL 360
AIGFGIGFLH KPDPTVLVED LKILKPYAVA LVPRILTRFE AGIKNALDKS TVQRNVANTI 420
LDSKSARFTA RGGPDKSIMN FLVYHRVLID KIRDSLGLSN NSFIITGSAP ISKDTLLFLR 480
SALDIGIRQG YGLTETFAGV CLSEPFEKDV GSCGAIGISA ECRLKSVPEM GYHADKDLKG 540
ELQIRGPQVF ERYFKNPNET SKAVDQDGWF STGDVAFIDG KGRISVIDRV KNFFKLAHGE 600
YIAPEKIENI YLSSCPYITQ IFVFGDPLKT FLVGIVGVDV DAAQPILAAK HPEVKTWTKE 660
VLVENLNRNK KLRKEFLNKI NKCTDGLQGF EKLHNIKVGL EPLTLEDDVV TPTFKIKRAK 720
ASKFFKDTLD QLYAEGSLVK TEKL 744 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0005777; C:peroxisome; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004467; F:long-chain fatty acid-CoA ligase activity; IDA:SGD. GO:0031956; F:medium-chain fatty acid-CoA ligase activity; IDA:SGD. GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IGI:SGD. GO:0006635; P:fatty acid beta-oxidation; IMP:UniProtKB. GO:0015916; P:fatty-acyl-CoA transport; IGI:UniProtKB. GO:0015910; P:peroxisomal long-chain fatty acid import; IGI:UniProtKB. GO:0042760; P:very long-chain fatty acid catabolic process; IGI:UniProtKB. |
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SMART | |
PROSITE | |
PRINTS | |