UniProt Accession

 CHIN_HUMAN; P15882; A8K1M6; B3KNU6; B4DV19; Q53SD6; Q53SH5; Q96FB0 

Genbank Protein ID

 X51408; Z22641; AK055060; AK289941; AK300890; AC007435; AC018890; AC020596; CH471058; CH471058; CH471058; BC011393; S75654 

Genbank Nucleotide ID

 CAA35769.1; CAA80354.1; BAG51458.1; BAF82630.1; BAG62531.1; AAY14688.1; AAY14940.1; EAX11117.1; EAX11118.1; EAX11119.1; AAH11393.1; AAB33506.1 

Protein Name

 N-chimaerin 

Protein Synonyms/Alias

 A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2 

Gene Name

 CHN1 

Gene Synonyms/Alias

 ARHGAP2; CHN 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	CEVENRPKYYGREFH	acetylation	[1]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. 

Sequence Annotation

 DOMAIN 49 135 SH2.
 DOMAIN 268 459 Rho-GAP.
 ZN_FING 205 255 Phorbol-ester/DAG-type.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 340 340 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Disease mutation; GTPase activation; Metal-binding; Neurogenesis; Phosphoprotein; Reference proteome; SH2 domain; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 459 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
 GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.
 GO:0008045; P:motor neuron axon guidance; ISS:UniProtKB.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0050770; P:regulation of axonogenesis; ISS:UniProtKB.
 GO:0032314; P:regulation of Rac GTPase activity; IEA:Compara.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. 

Interpro

 IPR020454; DAG/PE-bd.
 IPR017356; N-chimaerin.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom.
 IPR000980; SH2. 

Pfam

 PF00130; C1_1
 PF00620; RhoGAP
 PF00017; SH2 

SMART

 SM00109; C1
 SM00324; RhoGAP
 SM00252; SH2 

PROSITE

 PS50238; RHOGAP
 PS50001; SH2
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 

PRINTS

 PR00008; DAGPEDOMAIN.