CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028672
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Voltage-dependent N-type calcium channel subunit alpha-1B 
Protein Synonyms/Alias
  
Gene Name
 Cacna1b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
46PGQRVLYKQSIAQRAubiquitination[1]
65LYNPIPVKQNCFTVNubiquitination[1]
1254LRVLRPLKTIKRLPKacetylation[2]
1441IDFAISAKPLTRYMPubiquitination[1]
1815QCDAELRKEISSVWAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Calcium channel; Calcium transport; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2328 AA 
Protein Sequence
MVRFGDELGG RYGGTGGGER ARGGGAGGAG GPGQGGLPPG QRVLYKQSIA QRARTMALYN 60
PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM ILATIIANCI VLALEQHLPD 120
GDKTPMSERL DDTEPYFIGI FCFEAGIKII ALGFVFHKGS YLRNGWNVMD FVVVLTGILA 180
TAGTDFDLRT LRAVRVLRPL KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII 240
GLEFYMGKFH KACFPNSTDT EPVGDFPCGK DPPARQCDGD TECREYWPGP NFGITNFDNI 300
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL VLGVLSGEFA 360
KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML AEEDKNAEEK SPLDAVLKRA 420
ATKKSRNDLI HAEEGEDRFV DLCAVGSPFA RASLKSGKTE SSSYFRRKEK MFRFFIRRMV 480
KAQSFYWVVL CVVALNTLCV AMVHYNQPQR LTTALYFAEF VFLGLFLTEM SLKMYGLGPR 540
SYFRSSFNCF DFGVIVGSIF EVVWAAIKPG TSFGISVLRA LRLLRIFKVT KYWNSLRNLV 600
VSLLNSMKSI ISLLFLLFLF IVVFALLGMQ LFGGQFNFQD ETPTTNFDTF PAAILTVFQI 660
LTGEDWNAVM YHGIESQGGV SKGMFSSFYF IVLTLFGNYT LLNVFLAIAV DNLANAQELT 720
KDEEEMEEAA NQKLALQKAK EVAEVSPMSA ANISIAARQQ NSAKARSVWE QRASQLRLQN 780
LRASCEALYS EMDPEERLRY ASTRHVRPDM KTHMDRPLVV EPGRDGLRGP VGSKSKPEGT 840
EATESADLPR RHHRHRDRDK TSATAPAGGE QDRTESTETG AREERARPRR SHSKETPGAD 900
TQVRCERSRR HHRRGSPEEA TEREPRRHRA HRHAQDSSKE GTAPVLVPKG ERRARHRGPR 960
TGPREAENNE EPTRRHRARH KVPPTLQPPE REAAEKESNA VEGDKETRNH QPKEPHCDLE 1020
AIAVTGVGPL HMLPSTCLQK VDEQPEDADN QRNVTRMGSQ PSDPSTTVHV PVTLTGPPGE 1080
TPVVPSGNMN LEGQAEGKKE AEADDVLRRG PRPIVPYSSM FCLSPTNLLR RFCHYIVTMR 1140
YFEMVILVVI ALSSIALAAE DPVRTDSFRN NALKYMDYIF TGVFTFEMVI KMIDLGLLLH 1200
PGAYFRDLWN ILDFIVVSGA LVAFAFSSFM GGSKGKDINT IKSLRVLRVL RPLKTIKRLP 1260
KLKAVFDCVV NSLKNVLNIL IVYMLFMFIF AVIAVQLFKG KFFYCTDESK ELERDCRGQY 1320
LDYEKEEVEA QPRQWKKYDF HYDNVLWALL TLFTVSTGEG WPMVLKHSVD ATYEEQGPSP 1380
GFRMELSIFY VVYFVVFPFF FVNIFVALII ITFQEQGDKV MSECSLEKNE RACIDFAISA 1440
KPLTRYMPQN KQSFQYKTWT FVVSPPFEYF IMAMIALNTV VLMMKFYDAP YEYELMLKCL 1500
NIVFTSMFSM ECILKIIAFG VLNYFRDAWN VFDFVTVLGS ITDILVTEIA NNFINLSFLR 1560
LFRAARLIKL LRQGYTIRIL LWTFVQSFKA LPYVCLLIAM LFFIYAIIGM QVFGNIALDD 1620
DTSINRHNNF RTFLQALMLL FRSATGEAWH EIMLSCLGNR ACDPHANASE CGSDFAYFYF 1680
VSFIFLCSFL MLNLFVAVIM DNFEYLTRDS SILGPHHLDE FIRVWAEYDP AACGRISYND 1740
MFEMLKHMSP PLGLGKKCPA RVAYKRLVRM NMPISNEDMT VHFTSTLMAL IRTALEIKLA 1800
PAGTKQHQCD AELRKEISSV WANLPQKTLD LLVPPHKPDE MTVGKVYAAL MIFDFYKQNK 1860
TTRDQTHQAP GGLSQMGPVS LFHPLKATLE QTQPAVLRGA RVFLRQKSAT SLSNGGAIQT 1920
QESGIKESLS WGTQRTQDAL YEARAPLERG HSAEIPVGQS GTLAVDVQMQ NMTLRGPDGE 1980
PQPGLESQGR AASMPRLAAE TQPAPNASPM KRSISTLAPR PHGTQLCSTV LDRPPPSQAS 2040
HHHHHRCHRR RDKKQRSLEK GPSLSVDPEG APSTAAGPGL PHGEGSTACR RDRKQERGRS 2100
QERRQPSSSS SEKQRFYSCD RFGSREPPQL MPSLSSHPTS PTAALEPAPH PQGSGSVNGS 2160
PLMSTSGAST PGRGGRRQLP QTPLTPRPSI TYKTANSSPV HFAEGQSGLP AFSPGRLSRG 2220
LSEHNALLQK EPLSQPLAPG SRIGSDPYLG QRLDSEASAH TLPEDTLTFE EAVATNSGRS 2280
SRTSYVSSLT SQSHPLRRVP NGYHCTLGLS TGVRARHSYH HPDQDHWC 2328 
Gene Ontology
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005891; C:voltage-gated calcium channel complex; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005245; F:voltage-gated calcium channel activity; IMP:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0007269; P:neurotransmitter secretion; IMP:MGI.
 GO:0008217; P:regulation of blood pressure; IMP:MGI.
 GO:0051924; P:regulation of calcium ion transport; IMP:MGI.
 GO:0008016; P:regulation of heart contraction; IMP:MGI.
 GO:0048265; P:response to pain; IMP:MGI. 
Interpro
 IPR002048; EF_hand_dom.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR014873; VDCC_a1su_IQ.
 IPR005447; VDCC_N_a1su.
 IPR002077; VDCCAlpha1. 
Pfam
 PF08763; Ca_chan_IQ
 PF00520; Ion_trans 
SMART
 SM01062; Ca_chan_IQ 
PROSITE
 PS50222; EF_HAND_2 
PRINTS
 PR00167; CACHANNEL.
 PR01631; NVDCCALPHA1.