CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039592
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Lysine-specific demethylase 4B 
Protein Synonyms/Alias
  
Gene Name
 KDM4B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106RRLANSEKYCTPRHQubiquitination[1, 2]
242CDAFLRHKMTLISPIubiquitination[1]
253ISPIILKKYGIPFSRubiquitination[1]
302LRWIDYGKVATQCTCubiquitination[1]
334PERYELWKQGKDLTVubiquitination[1]
337YELWKQGKDLTVLDHubiquitination[1]
636QAPSTFSKLKMEIKKubiquitination[1, 3]
757LPSKSRQKTRPLIPEubiquitination[1]
885PEQRWKLKCVYCRKRubiquitination[1]
962LGQVVITKNRNGLYYubiquitination[1]
1028WTDGNLYKAKFISSVubiquitination[1]
1066TLEEELPKRVRSRLSubiquitination[1]
1090AFSGEEAKAAKRPRVubiquitination[1, 4]
1093GEEAKAAKRPRVGTPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1130 AA 
Protein Sequence
MGSEDHGAQN PSCKIMTFRP TMEEFKDFNK YVAYIESQGA HRAGLAKIIP PKEWKPRQTY 60
DDIDDVVIPA PIQQVVTGQS GLFTQYNIQK KAMTVGEYRR LANSEKYCTP RHQDFDDLER 120
KYWKNLTFVS PIYGADISGS LYDDDVAQWN IGSLRTILDM VERECGTIIE GVNTPYLYFG 180
MWKTTFAWHT EDMDLYSINY LHFGEPKSWY AIPPEHGKRL ERLAIGFFPG SSQGCDAFLR 240
HKMTLISPII LKKYGIPFSR ITQEAGEFMI TFPYGYHAGF NHGFNCAEST NFATLRWIDY 300
GKVATQCTCR KDMVKISMDV FVRILQPERY ELWKQGKDLT VLDHTRPTAL TSPELSSWSA 360
SRASLKAKLL RRQISLKENR HWRKTEEERK PSLERKKEQT KRPGLSSHRK RSQPKKPKPE 420
DPKFPGEGTA GAALLEEAGG SVKEEAGPEV DPEEEEEEPQ PLPHGREAEG AEEDGRGKLR 480
PTKAKSERKK KSFGLLPPQL PPPPAHFPSE EALWLPSPLE PPVLGPGPAA MEESPLPAPL 540
NVVPPEVPSE ELEAKPRPII PMLYVVPRPG KAAFNQEHVS CQQAFEHFAQ KGPTWKEPVS 600
PMELTGPEDG AASSGAGRME TKARAGEGQA PSTFSKLKME IKKSRRHPLG RPPTRSPLSV 660
VKQEASSDEE ASPFSGEEDV SDPDALRPLL SLQWKNRAAS FQAERKFNAA AARTEPYCAI 720
CTLFYPYCQA LQTEKEAPIA SLGKGCPATL PSKSRQKTRP LIPEMCFTSG GENTEPLPAN 780
SYIGDDGTSP LIACGKCCLQ VHASCYGIRP ELVNEGWTCS RCAAHAWTAE CCLCNLRGGA 840
LQMTTDRRWI HVICAIAVPE ARFLNVIERH PVDISAIPEQ RWKLKCVYCR KRMKKVSGAC 900
IQCSYEHCST SFHVTCAHAA GVLMEPDDWP YVVSITCLKH KSGGHAVQLL RAVSLGQVVI 960
TKNRNGLYYR CRVIGAASQT CYEVNFDDGS YSDNLYPESI TSRDCVQLGP PSEGELVELR 1020
WTDGNLYKAK FISSVTSHIY QVEFEDGSQL TVKRGDIFTL EEELPKRVRS RLSLSTGAPQ 1080
EPAFSGEEAK AAKRPRVGTP LATEDSGRSQ DYVAFVESLL QVQGRPGAPF 1130 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR003347; JmjC_dom.
 IPR003349; TF_JmjN.
 IPR002999; Tudor.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF02373; JmjC
 PF02375; JmjN 
SMART
 SM00558; JmjC
 SM00545; JmjN
 SM00249; PHD
 SM00333; TUDOR 
PROSITE
 PS51184; JMJC
 PS51183; JMJN 
PRINTS