CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017010
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitofusin-1 
Protein Synonyms/Alias
 Fzo homolog; Transmembrane GTPase MFN1 
Gene Name
 MFN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
9AEPVSPLKHFVLAKKubiquitination[1]
61LVEMQGYKDKLSIIGubiquitination[2]
63EMQGYKDKLSIIGEVubiquitination[2]
286RIFFVSAKEVLSARKubiquitination[2]
345EQHTIRAKQILATVKubiquitination[2]
365VNLAAEDKRHYSVEEubiquitination[2]
395NLLTLDVKKKIKEVTubiquitination[2]
396LLTLDVKKKIKEVTEubiquitination[2]
399LDVKKKIKEVTEEVAubiquitination[2]
542FVNYATEKLRMIVSSubiquitination[2]
596KEIDQLEKIQNNSKLubiquitination[2]
602EKIQNNSKLLRNKAVubiquitination[2]
607NSKLLRNKAVQLENEubiquitination[2]
620NELENFTKQFLPSSNubiquitination[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. 
Sequence Annotation
 NP_BIND 82 89 GTP (Probable).
 NP_BIND 178 182 GTP (Probable).
 NP_BIND 237 240 GTP (Probable).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; GTP-binding; Hydrolase; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 741 AA 
Protein Sequence
MAEPVSPLKH FVLAKKAITA IFDQLLEFVT EGSHFVEATY KNPELDRIAT EDDLVEMQGY 60
KDKLSIIGEV LSRRHMKVAF FGRTSSGKSS VINAMLWDKV LPSGIGHITN CFLSVEGTDG 120
DKAYLMTEGS DEKKSVKTVN QLAHALHMDK DLKAGCLVRV FWPKAKCALL RDDLVLVDSP 180
GTDVTTELDS WIDKFCLDAD VFVLVANSES TLMNTEKHFF HKVNERLSKP NIFILNNRWD 240
ASASEPEYME DVRRQHMERC LHFLVEELKV VNALEAQNRI FFVSAKEVLS ARKQKAQGMP 300
ESGVALAEGF HARLQEFQNF EQIFEECISQ SAVKTKFEQH TIRAKQILAT VKNIMDSVNL 360
AAEDKRHYSV EEREDQIDRL DFIRNQMNLL TLDVKKKIKE VTEEVANKVS CAMTDEICRL 420
SVLVDEFCSE FHPNPDVLKI YKSLPRSLAS TPTAPTTPAT PDNASQEELM ITLVTGLASV 480
TSRTSMGIII VGGVIWKTIG WKLLSVSLTM YGALYLYERL SWTTHAKERA FKQQFVNYAT 540
EKLRMIVSST SANCSHQVKQ QIATTFARLC QQVDITQKQL EEEIARLPKE IDQLEKIQNN 600
SKLLRNKAVQ LENELENFTK QFLPSSNEES 630 
Gene Ontology
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; NAS:UniProtKB.
 GO:0008053; P:mitochondrial fusion; IDA:BHF-UCL. 
Interpro
 IPR001401; Dynamin_GTPase.
 IPR006884; Fzo/mitofusin_HR2.
 IPR027088; Mitofusin-1.
 IPR027094; Mitofusin_fam.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00350; Dynamin_N
 PF04799; Fzo_mitofusin 
SMART
  
PROSITE
  
PRINTS