UniProt Accession

 H0Y9Z4_HUMAN; H0Y9Z4 

Genbank Protein ID

 AC004707 

Genbank Nucleotide ID

  

Protein Name

 Crossover junction endonuclease EME1 

Protein Synonyms/Alias

  

Gene Name

 EME1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
82	AALVTRMKAQRPEEC	ubiquitination	[1]
152	LDSTMKGKETLQGFV	ubiquitination	[1, 2]
165	FVTDITAKTAGKALS	ubiquitination	[1]
169	ITAKTAGKALSLVIV	ubiquitination	[1, 2]
253	DFTCAFTKAVAEAPF	ubiquitination	[1]
262	VAEAPFKKLRDETTF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004518; F:nuclease activity; IEA:InterPro.
 GO:0006259; P:DNA metabolic process; IEA:InterPro.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 

Interpro

 IPR006166; ERCC4_domain. 

Pfam

 PF02732; ERCC4 

SMART

 SM00891; ERCC4 

PROSITE

  

PRINTS