CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000938
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lymphocyte antigen 75 
Protein Synonyms/Alias
 Ly-75; C-type lectin domain family 13 member B; DEC-205; gp200-MR6; CD205 
Gene Name
 LY75 
Gene Synonyms/Alias
 CD205; CLEC13B 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1781IKTGEWKKGNCEVSSmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. 
Sequence Annotation
 DOMAIN 33 156 Ricin B-type lectin.
 DOMAIN 164 211 Fibronectin type-II.
 DOMAIN 225 341 C-type lectin 1.
 DOMAIN 368 486 C-type lectin 2.
 DOMAIN 493 625 C-type lectin 3.
 DOMAIN 652 778 C-type lectin 4.
 DOMAIN 818 931 C-type lectin 5.
 DOMAIN 958 1091 C-type lectin 6.
 DOMAIN 1110 1222 C-type lectin 7.
 DOMAIN 1251 1374 C-type lectin 8.
 DOMAIN 1401 1513 C-type lectin 9.
 DOMAIN 1542 1661 C-type lectin 10.
 MOD_RES 933 933 Phosphotyrosine.
 MOD_RES 1703 1703 Phosphoserine (By similarity).
 CARBOHYD 135 135 N-linked (GlcNAc...) (Potential).
 CARBOHYD 345 345 N-linked (GlcNAc...) (Potential).
 CARBOHYD 377 377 N-linked (GlcNAc...) (Potential).
 CARBOHYD 529 529 N-linked (GlcNAc...) (Potential).
 CARBOHYD 843 843 N-linked (GlcNAc...) (Potential).
 CARBOHYD 865 865 N-linked (GlcNAc...) (Potential).
 CARBOHYD 934 934 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1076 1076 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1103 1103 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1225 1225 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1320 1320 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1392 1392 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1593 1593 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1626 1626 N-linked (GlcNAc...) (Potential).
 DISULFID 169 194 By similarity.
 DISULFID 183 209 By similarity.
 DISULFID 247 340 By similarity.
 DISULFID 317 332 By similarity.
 DISULFID 389 485 By similarity.
 DISULFID 462 477 By similarity.
 DISULFID 597 614 By similarity.
 DISULFID 840 930 By similarity.
 DISULFID 904 922 By similarity.
 DISULFID 1060 1080 By similarity.
 DISULFID 1197 1211 By similarity.
 DISULFID 1488 1502 By similarity.
 DISULFID 1635 1650 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Endocytosis; Glycoprotein; Lectin; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1722 AA 
Protein Sequence
MRTGWATPRR PAGLLMLLFW FFDLAEPSGR AANDPFTIVH GNTGKCIKPV YGWIVADDCD 60
ETEDKLWKWV SQHRLFHLHS QKCLGLDITK SVNELRMFSC DSSAMLWWKC EHHSLYGAAR 120
YRLALKDGHG TAISNASDVW KKGGSEESLC DQPYHEIYTR DGNSYGRPCE FPFLIDGTWH 180
HDCILDEDHS GPWCATTLNY EYDRKWGICL KPENGCEDNW EKNEQFGSCY QFNTQTALSW 240
KEAYVSCQNQ GADLLSINSA AELTYLKEKE GIAKIFWIGL NQLYSARGWE WSDHKPLNFL 300
NWDPDRPSAP TIGGSSCARM DAESGLWQSF SCEAQLPYVC RKPLNNTVEL TDVWTYSDTR 360
CDAGWLPNNG FCYLLVNESN SWDKAHAKCK AFSSDLISIH SLADVEVVVT KLHNEDIKEE 420
VWIGLKNINI PTLFQWSDGT EVTLTYWDEN EPNVPYNKTP NCVSYLGELG QWKVQSCEEK 480
LKYVCKRKGE KLNDASSDKM CPPDEGWKRH GETCYKIYED EVPFGTNCNL TITSRFEQEY 540
LNDLMKKYDK SLRKYFWTGL RDVDSCGEYN WATVGGRRRA VTFSNWNFLE PASPGGCVAM 600
STGKSVGKWE VKDCRSFKAL SICKKMSGPL GPEEASPKPD DPCPEGWQSF PASLSCYKVF 660
HAERIVRKRN WEEAERFCQA LGAHLSSFSH VDEIKEFLHF LTDQFSGQHW LWIGLNKRSP 720
DLQGSWQWSD RTPVSTIIMP NEFQQDYDIR DCAAVKVFHR PWRRGWHFYD DREFIYLRPF 780
ACDTKLEWVC QIPKGRTPKT PDWYNPDRAG IHGPPLIIEG SEYWFVADLH LNYEEAVLYC 840
ASNHSFLATI TSFVGLKAIK NKIANISGDG QKWWIRISEW PIDDHFTYSR YPWHRFPVTF 900
GEECLYMSAK TWLIDLGKPT DCSTKLPFIC EKYNVSSLEK YSPDSAAKVQ CSEQWIPFQN 960
KCFLKIKPVS LTFSQASDTC HSYGGTLPSV LSQIEQDFIT SLLPDMEATL WIGLRWTAYE 1020
KINKWTDNRE LTYSNFHPLL VSGRLRIPEN FFEEESRYHC ALILNLQKSP FTGTWNFTSC 1080
SERHFVSLCQ KYSEVKSRQT LQNASETVKY LNNLYKIIPK TLTWHSAKRE CLKSNMQLVS 1140
ITDPYQQAFL SVQALLHNSS LWIGLFSQDD ELNFGWSDGK RLHFSRWAET NGQLEDCVVL 1200
DTDGFWKTVD CNDNQPGAIC YYSGNETEKE VKPVDSVKCP SPVLNTPWIP FQNCCYNFII 1260
TKNRHMATTQ DEVHTKCQKL NPKSHILSIR DEKENNFVLE QLLYFNYMAS WVMLGITYRN 1320
KSLMWFDKTP LSYTHWRAGR PTIKNEKFLA GLSTDGFWDI QTFKVIEEAV YFHQHSILAC 1380
KIEMVDYKEE YNTTLPQFMP YEDGIYSVIQ KKVTWYEALN MCSQSGGHLA SVHNQNGQLF 1440
LEDIVKRDGF PLWVGLSSHD GSESSFEWSD GSTFDYIPWK GQTSPGNCVL LDPKGTWKHE 1500
KCNSVKDGAI CYKPTKSKKL SRLTYSSRCP AAKENGSRWI QYKGHCYKSD QALHSFSEAK 1560
KLCSKHDHSA TIVSIKDEDE NKFVSRLMRE NNNITMRVWL GLSQHSVDQS WSWLDGSEVT 1620
FVKWENKSKS GVGRCSMLIA SNETWKKVEC EHGFGRVVCK VPLDCPSSTW IQFQDSCYIF 1680
LQEAIKVESI EDVRNQCTDH GADMISIHNE EENAFILDTL KKQWKGPDDI LLGMFYDTDD 1740
ASFKWFDNSN MTFDKWTDQD DDEDLVDTCA FLHIKTGEWK KGNCEVSSVE GTLCKTAIPY 1800
KRKYLSDNHI LISALVIAST VILTVLGAII WFLYKKHSDS RFTTVFSTAP QSPYNEDCVL 1860
VVGEENEYPV QFD 1873 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0006954; P:inflammatory response; TAS:ProtInc. 
Interpro
 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR018378; C-type_lectin_CS.
 IPR016187; C-type_lectin_fold.
 IPR000562; FN_type2_col-bd.
 IPR013806; Kringle-like.
 IPR000772; Ricin_B_lectin. 
Pfam
 PF00040; fn2
 PF00059; Lectin_C 
SMART
 SM00034; CLECT
 SM00059; FN2
 SM00458; RICIN 
PROSITE
 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2
 PS00023; FN2_1
 PS51092; FN2_2
 PS50231; RICIN_B_LECTIN 
PRINTS