| Tag | Content |
|---|
| CPLM ID | CPLM-022637 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tight junction protein ZO-3 |
Protein Synonyms/Alias | Tight junction protein 3; Zona occludens protein 3; Zonula occludens protein 3 |
Gene Name | Tjp3 |
Gene Synonyms/Alias | Zo3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 186 | DVLMRPLKSVLVKRR | ubiquitination | [1] | | 653 | DSPSKIIKLDTVRVI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | DOMAIN 11 93 PDZ 1.
DOMAIN 187 264 PDZ 2.
DOMAIN 368 434 PDZ 3.
DOMAIN 467 540 SH3.
DOMAIN 573 754 Guanylate kinase-like.
MOD_RES 111 111 Phosphoserine.
MOD_RES 151 151 Phosphoserine.
MOD_RES 156 156 Phosphoserine.
MOD_RES 157 157 Phosphoserine.
MOD_RES 161 161 Phosphoserine.
MOD_RES 195 195 Phosphoserine.
MOD_RES 323 323 Phosphothreonine.
MOD_RES 557 557 Phosphoserine.
MOD_RES 584 584 Phosphoserine.
MOD_RES 891 891 Phosphoserine.
MOD_RES 892 892 Phosphoserine. |
Keyword | Cell junction; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat; SH3 domain; Tight junction. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 905 AA |
Protein Sequence | MEELTIWEQH TATLYKDPRR GFGIAVSGGH DRASGSVVVS DVVPGSPAEG RLRTGDHIVM 60
VNGVSVENVT SAFAIQILKT CTKTANVTVK RPRRVQLPAT KASPASGHQL SDQEEADHGR 120
GYEGDSSSGS GRSWGERSRR SRAGRRGRVG SHGRRSSGGG SEANGLDLVS GYKRLPKQDV 180
LMRPLKSVLV KRRNSEEFGV KLGSQIFIKH ITESGLAARN HGLQEGDLIL QINGVSSANL 240
SLSDTRRLIE KSEGELTLLV LRDSGQFLVN IPPAVSDSDS SLMEDISDLT SELSQAPPSH 300
VPPPPLKGQR SPEDSQTDSP VETPQPRRRE RSVNSRAIAE PESPGESRYD IYRVPSRQSL 360
EDRGYSPDTR VVSFPKGASI GLRLAGGNDV GIFVSGVQAG SPADGQGIQE GDEILQVNGM 420
PFRNLTREEA VQFLLGLPPG EDMELVTQSK TGHSLRRWSQ SRVGDSFYIR THFELEPSPP 480
YGLGFTRGDV FHVVDTLYPG SGPGHGHSSH GGLWLAARMG RDLREQERGV IPNQSRAEQL 540
ASLEAAQRAA GVGPGASVGS NPRAEFWRLR SLRRGTKKAS TQRSREDLSA LTRQGHYPPY 600
ERVVLREASF KRPVVILGPV ADIAMKKLTT EMPEEFEIAE SMSRTDSPSK IIKLDTVRVI 660
AERDKHALLD VTPSAIERLN YVQYYPIVIF CAPESRPALK ALREWLAPAS RRSSRRLYAQ 720
AQKLQKHSGH LFTATIPLHG TSDSWYQEVK AVIQQQQARP IWTAEDQLNS SSEDLDLTGH 780
GLAASSGDLS CDSRTNSDYE DTDGEGAYTD REGGPQDVDE EVAPTALARS SEPVWVDDHQ 840
GLMGHGTTIT DKWETQADSH YTQDQRRQDS MRTYKHEALR KKFTRARDVE SSDDEGYDWG 900
PATDL 905 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IDA:MGI. GO:0005923; C:tight junction; IDA:MGI. GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IGI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |