| Tag | Content |
|---|
| CPLM ID | CPLM-002734 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 2 subunit beta |
Protein Synonyms/Alias | eIF-2-beta |
Gene Name | SUI3 |
Gene Synonyms/Alias | TIF212; YPL237W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 102 | AFEKELAKAGLDNVD | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
Sequence Annotation | ZN_FING 236 262 C4-type (Potential).
MOD_RES 40 40 Phosphoserine.
MOD_RES 69 69 Phosphothreonine.
MOD_RES 80 80 Phosphoserine.
MOD_RES 92 92 Phosphoserine.
MOD_RES 112 112 Phosphoserine.
MOD_RES 116 116 Phosphothreonine.
MOD_RES 118 118 Phosphoserine. |
Keyword | Complete proteome; Initiation factor; Metal-binding; Phosphoprotein; Protein biosynthesis; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 285 AA |
Protein Sequence | MSSDLAAELG FDPALKKKKK TKKVIPDDFD AAVNGKENGS GDDLFAGLKK KKKKSKSVSA 60
DAEAEKEPTD DIAEALGELS LKKKKKKTKD SSVDAFEKEL AKAGLDNVDA ESKEGTPSAN 120
SSIQQEVGLP YSELLSRFFN ILRTNNPELA GDRSGPKFRI PPPVCLRDGK KTIFSNIQDI 180
AEKLHRSPEH LIQYLFAELG TSGSVDGQKR LVIKGKFQSK QMENVLRRYI LEYVTCKTCK 240
SINTELKREQ SNRLFFMVCK SCGSTRSVSS IKTGFQATVG KRRRM 285 |
Gene Ontology | GO:0005850; C:eukaryotic translation initiation factor 2 complex; IMP:SGD. GO:0043614; C:multi-eIF complex; IDA:SGD. GO:0005840; C:ribosome; TAS:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0003743; F:translation initiation factor activity; TAS:SGD. |
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