| Tag | Content |
|---|
| CPLM ID | CPLM-005583 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | MAP/microtubule affinity-regulating kinase 3 |
Protein Synonyms/Alias | C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Par-1a; Serine/threonine-protein kinase p78 |
Gene Name | MARK3 |
Gene Synonyms/Alias | CTAK1; EMK2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 317 | FLVLNPIKRGTLEQI | ubiquitination | [1] | | 353 | ELDISDQKRIDIMVG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. |
Sequence Annotation | DOMAIN 56 307 Protein kinase.
DOMAIN 326 365 UBA.
DOMAIN 704 753 KA1.
NP_BIND 62 70 ATP (By similarity).
ACT_SITE 178 178 Proton acceptor (By similarity).
BINDING 85 85 ATP (By similarity).
MOD_RES 42 42 Phosphoserine.
MOD_RES 211 211 Phosphothreonine; by LKB1.
MOD_RES 383 383 Phosphoserine.
MOD_RES 400 400 Phosphoserine.
MOD_RES 469 469 Phosphoserine.
MOD_RES 549 549 Phosphothreonine.
MOD_RES 564 564 Phosphothreonine; by PKC/PRKCZ (By
MOD_RES 598 598 Phosphoserine.
MOD_RES 643 643 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 753 AA |
Protein Sequence | MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 60
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120
VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QGCQAGQTIK VQVSFDLLSL 180
MFTFIVSAVQ YCHQKRIVHR DLKAENLLLD ADMNIKIADF GFSNEFTVGG KLDTFCGSPP 240
YAAPELFQGK KYDGPEVDVW SLGVILYTLV SGSLPFDGQN LKELRERVLR GKYRIPFYMS 300
TDCENLLKRF LVLNPIKRGT LEQIMKDRWI NAGHEEDELK PFVEPELDIS DQKRIDIMVG 360
MGYSQEEIQE SLSKMKYDEI TATYLLLGRK SSEVRPSSDL NNSTGQSPHH KVQRSVFSSQ 420
KQRRYSDHAG PAIPSVVAYP KRSQTSTADS DLKEDGISSR KSSGSAVGGK GIAPASPMLG 480
NASNPNKADI PERKKSSTVP SSNTASGGMT RRNTYVCSER TTADRHSVIQ NGKENSTIPD 540
QRTPVASTHS ISSAATPDRI RFPRGTASRS TFHGQPRERR TATYNGPPAS PSLSHEATPL 600
SQTRSRGSTN LFSKLTSKLT RRNMSFRFIK RLPTEYERNG RYEGSSRNVS AEQKDENKEA 660
KPRSLRFTWS MKTTSSMDPG DMMREIRKVL DANNCDYEQR ERFLLFCVHG DGHAENLVQW 720
EMEVCKLPRL SLNGVRFKRI SGTSIAFKNI ASKIANELKL 760 |
Gene Ontology | GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |