CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022756
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine deaminase 
Protein Synonyms/Alias
 Guanase; Guanine aminase; Guanine aminohydrolase; GAH 
Gene Name
 Gda 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
53EESSQQEKLAKEWCFubiquitination[1]
61LAKEWCFKPCEIRELubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. 
Sequence Annotation
 METAL 82 82 Zinc; via tele nitrogen (By similarity).
 METAL 84 84 Zinc; via tele nitrogen (By similarity).
 METAL 240 240 Zinc; via tele nitrogen (By similarity).
 METAL 330 330 Zinc (By similarity).
 BINDING 87 87 Substrate (By similarity).
 BINDING 213 213 Substrate (By similarity).
 BINDING 243 243 Substrate (By similarity).
 BINDING 279 279 Substrate (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Hydrolase; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 454 AA 
Protein Sequence
MCAARTPPLA LVFRGTFVHS TWTCPMEVLR DHLLGVSDSG KIVFLEESSQ QEKLAKEWCF 60
KPCEIRELSH HEFFMPGLVD THIHAPQYAF AGSNVDLPLL EWLNKYTFPT EQRFRSTDVA 120
EEVYTRVVRR TLKNGTTTAC YFGTIHTDSS LILAEITDKF GQRAFVGKVC MDLNDTVPEY 180
KETTEESVKE TERFVSEMLQ KNYPRVKPIV TPRFTLSCTE TLMSELGNIA KTHDLYIQSH 240
ISENREEIEA VKSLYPSYKN YTDVYDKNNL LTNKTVMAHG CYLSEEELNI FSERGASIAH 300
CPNSNLSLSS GLLNVLEVLK HKVKIGLGTD VAGGYSYSML DAIRRAVMVS NVLLINKVNE 360
KNLTLKEVFR LATLGGSQAL GLDSEIGNFE VGKEFDALLI NPRASDSPID LFYGDFVGDI 420
SEAVIQKFLY LGDDRNIEEV YVGGKQVVPF SSSV 454 
Gene Ontology
 GO:0008892; F:guanine deaminase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006147; P:guanine catabolic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR006680; Amidohydro_1.
 IPR014311; Guanine_deaminase. 
Pfam
 PF01979; Amidohydro_1 
SMART
  
PROSITE
  
PRINTS