UniProt Accession

 TMM59_MOUSE; Q9QY73; Q3TWB4; Q99LY8; Q9D1P9 

Genbank Protein ID

 AF116911; AK003252; AK050162; AK145644; AK159761; AK166772; AK167058; BC002164; BC014732; BC018379; BC045145; BC058273 

Genbank Nucleotide ID

 AAF20283.1; BAB22668.2; BAC34103.1; BAE26561.1; BAE35352.1; BAE39008.1; BAE39221.1; AAH02164.1; AAH14732.1; AAH18379.1; AAH45145.1; AAH58273.1 

Protein Name

 Transmembrane protein 59 

Protein Synonyms/Alias

 Thymic dendritic cell-derived factor 1 

Gene Name

 Tmem59 

Gene Synonyms/Alias

 ORF18; Tdcf1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
287	LEFMNEQKLSRYPAP	ubiquitination	[1]
315	EAGPLPTKVNLAHSE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding (By similarity). 

Sequence Annotation

 MOTIF 263 281 ATG16L1-binding motif.
 CARBOHYD 90 90 N-linked (GlcNAc...) (Potential).  

Keyword

 Autophagy; Cell membrane; Complete proteome; Direct protein sequencing; Endosome; Glycoprotein; Golgi apparatus; Lysosome; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005770; C:late endosome; ISS:UniProtKB.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004175; F:endopeptidase activity; IDA:MGI.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB. 

Interpro

 IPR022065; Uncharacterised_TMEM59. 

Pfam

 PF12280; BSMAP 

SMART

  

PROSITE

  

PRINTS