CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016622
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Amine oxidase [flavin-containing] B 
Protein Synonyms/Alias
 Monoamine oxidase type B; MAO-B 
Gene Name
 Maob 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
52TIRNKNVKYVDLGGSacetylation[1, 2, 3]
52TIRNKNVKYVDLGGSubiquitination[4]
73NRILRLAKELGLETYubiquitination[4]
81ELGLETYKVNEVERLacetylation[3]
81ELGLETYKVNEVERLubiquitination[4]
93ERLIHFVKGKSYAFRacetylation[3]
136IPSDAPWKAPLAEEWubiquitination[4]
154TMKELLDKICWTKSTubiquitination[4]
159LDKICWTKSTKQIATubiquitination[4]
209TNGGQERKFIGGSGQubiquitination[4]
222GQVSERIKDILGDRVacetylation[3, 5]
222GQVSERIKDILGDRVubiquitination[4]
230DILGDRVKLERPVIHubiquitination[4]
248TGENVIVKTLNHEIYacetylation[6]
248TGENVIVKTLNHEIYubiquitination[4]
258NHEIYEAKYVISAIPubiquitination[4]
302IKCMVYYKEPFWRKKacetylation[3]
363TKEERLRKLCELYAKacetylation[6]
363TKEERLRKLCELYAKubiquitination[4]
370KLCELYAKVLNSQEAacetylation[3, 5]
370KLCELYAKVLNSQEAubiquitination[4]
386QPVHYEEKNWCEEQYacetylation[5]
Reference
 [1] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [2] Proteomics of mitochondrial inner and outer membranes.
 Distler AM, Kerner J, Hoppel CL.
 Proteomics. 2008 Oct;8(19):4066-82. [PMID: 18763707]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
 Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 52 52 N6-acetyllysine.
 MOD_RES 397 397 S-8alpha-FAD cysteine (By similarity).  
Keyword
 Acetylation; Complete proteome; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MSNKSDVIVV GGGISGMAAA KLLHDCGLSV VVLEARDRVG GRTYTIRNKN VKYVDLGGSY 60
VGPTQNRILR LAKELGLETY KVNEVERLIH FVKGKSYAFR GPFPPVWNPI TYLDNNNLWR 120
TMDEMGQEIP SDAPWKAPLA EEWDYMTMKE LLDKICWTKS TKQIATLFVN LCVTAETHEV 180
SALWFLWYVK QCGGTTRIIS TTNGGQERKF IGGSGQVSER IKDILGDRVK LERPVIHIDQ 240
TGENVIVKTL NHEIYEAKYV ISAIPPALGM KIHYSPPLPM LRNQLISRVP LGSVIKCMVY 300
YKEPFWRKKD FCGTMVIEGE EAPIAYTLDD TKPDGTYAAI MGFILAHKAR KLVRLTKEER 360
LRKLCELYAK VLNSQEALQP VHYEEKNWCE EQYSGGCYTT YFPPGILTQY GRVLRQPVGK 420
IFFAGTETAS HWSGYMEGAV EAGERAAREI LHAIGKIPED EIWQPEPESL DVPARPITST 480
FLERHLPSVP GLLKLFGLTT ILSATALGFL AHKRGLFVHF 520 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:Compara.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0014063; P:negative regulation of serotonin secretion; IEA:Compara.
 GO:0045964; P:positive regulation of dopamine metabolic process; IEA:Compara.
 GO:0010044; P:response to aluminum ion; IEA:Compara.
 GO:0051412; P:response to corticosterone stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0010269; P:response to selenium ion; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara. 
Interpro
 IPR002937; Amino_oxidase.
 IPR001613; Flavin_amine_oxidase. 
Pfam
 PF01593; Amino_oxidase 
SMART
  
PROSITE
  
PRINTS
 PR00757; AMINEOXDASEF.