CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020388
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pantothenate kinase 2, mitochondrial 
Protein Synonyms/Alias
 hPanK2; Pantothenic acid kinase 2 
Gene Name
 PANK2 
Gene Synonyms/Alias
 C20orf48 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
231KLVYFEPKDITAEEEubiquitination[1]
246EEEVESLKSIRKYLTubiquitination[1, 2, 3, 4]
250ESLKSIRKYLTSNVAubiquitination[1]
271RDVHLELKDLTLCGRubiquitination[1]
478SFGNMMSKEKREAVSubiquitination[3]
480GNMMSKEKREAVSKEubiquitination[1]
486EKREAVSKEDLARATubiquitination[4]
543YALDYWSKGQLKALFubiquitination[5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May be the master regulator of the CoA biosynthesis (By similarity). 
Sequence Annotation
 BINDING 392 392 Acetyl-CoA (By similarity).
 BINDING 395 395 Acetyl-CoA (By similarity).
 BINDING 407 407 Acetyl-CoA (By similarity).
 MOD_RES 168 168 Phosphoserine.
 MOD_RES 169 169 Phosphoserine.
 MOD_RES 189 189 Phosphoserine.  
Keyword
 Alternative initiation; Alternative splicing; ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm; Disease mutation; Kinase; Mitochondrion; Neurodegeneration; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 570 AA 
Protein Sequence
MRRLGPFHPR VHWAAPPSLS SGLHRLLFLR GTRIPSSTTL SPPRHDSLSL DGGTVNPPRV 60
REPTGREAFG PSPASSDWLP ARWRNGRGGR PRARLCSGWT AAEEARRNPT LGGLLGRQRL 120
LLRMGGGRLG APMERHGRAS ATSVSSAGEQ AAGDPEGRRQ EPLRRRASSA SVPAVGASAE 180
GTRRDRLGSY SGPTSVSRQR VESLRKKRPL FPWFGLDIGG TLVKLVYFEP KDITAEEEEE 240
EVESLKSIRK YLTSNVAYGS TGIRDVHLEL KDLTLCGRKG NLHFIRFPTH DMPAFIQMGR 300
DKNFSSLHTV FCATGGGAYK FEQDFLTIGD LQLCKLDELD CLIKGILYID SVGFNGRSQC 360
YYFENPADSE KCQKLPFDLK NPYPLLLVNI GSGVSILAVY SKDNYKRVTG TSLGGGTFFG 420
LCCLLTGCTT FEEALEMASR GDSTKVDKLV RDIYGGDYER FGLPGWAVAS SFGNMMSKEK 480
REAVSKEDLA RATLITITNN IGSIARMCAL NENINQVVFV GNFLRINTIA MRLLAYALDY 540
WSKGQLKALF SEHEGYFGAV GALLELLKIP 570 
Gene Ontology
 GO:0005758; C:mitochondrial intermembrane space; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004594; F:pantothenate kinase activity; IEA:EC.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009108; P:coenzyme biosynthetic process; TAS:Reactome.
 GO:0015939; P:pantothenate metabolic process; TAS:Reactome. 
Interpro
 IPR004567; Type_II_PanK. 
Pfam
 PF03630; Fumble 
SMART
  
PROSITE
  
PRINTS