| Tag | Content |
|---|
| CPLM ID | CPLM-017344 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dedicator of cytokinesis protein 4 |
Protein Synonyms/Alias | |
Gene Name | DOCK4 |
Gene Synonyms/Alias | KIAA0716 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 101 | RDWGTMWKQLYVRNE | ubiquitination | [1] | | 1137 | LFNSILLKKIERETW | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. |
Sequence Annotation | DOMAIN 6 67 SH3.
DOMAIN 401 574 DHR-1.
DOMAIN 1190 1596 DHR-2.
MOTIF 1788 1794 SH3-binding (Potential).
MOD_RES 167 167 Phosphotyrosine (By similarity).
MOD_RES 1614 1614 Phosphoserine.
MOD_RES 1618 1618 Phosphoserine.
MOD_RES 1620 1620 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; SH3 domain; SH3-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1966 AA |
Protein Sequence | MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN PNIKGIFPSS 60
YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW KQLYVRNEGD LFHRLWHIMN 120
EILDLRRQVL VGHLTHDRMK DVKRHITARL DWGNEQLGLD LVPRKEYAMV DPEDISITEL 180
YRLMEHRHRK KDTPVQASSH HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR 240
LNRNGLPKAP DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 300
FGCAVLSIAD LLTGETKDDL ILKVYMCNTE SEWYQIHENI IKKLNARYNL TGSNAGLAVS 360
LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSNIIMPGEM RNDLYITIER GEFEKGGKSV 420
ARNVEVTMFI VDSSGQTLKD FISFGSGEPP ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF 480
RGAHIRFEFR HCSTKEKGEK KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT 540
RYLKLPFSKG IFLGNNNQAM KATKESFCIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 600
LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ DSKFHHFKPV 660
MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE VLKAQEYIFK YIVQSRRLFS 720
LATGGQNEEE FRCCIQELLM SVRFFLSQES KGSGALSQSQ AVFLSSFPAV YSELLKLFDV 780
REVANLVQDT LGSLPTILHV DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI 840
HLQEQKDLIM CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQPS 900
SSAMRFQFQD VTGEFVACLL SLLRQMTDRH YQQLLDSFNT KEELRDFLLQ IFTVFRILIR 960
PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD YKIWDSYFYL AVIFINQLCL 1020
QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS MWQNLGEHKL HFIPALIGPF LEVTLIPQPD 1080
LRNVMIPIFH DMMDWEQRRS GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSILLKKIE 1140
RETWRESGVS LIATVTRLME RLLDYRDCMK MGEVDGKKIG CTVSLLNFYK TELNKEEMYI 1200
RYIHKLYDLH LKAQNFTEAA YTLLLYDELL EWSDRPLREF LTYPMQTEWQ RKEHLHLTII 1260
QNFDRGKCWE NGIILCRKIA EQYESYYDYR NLSKMRMMEA SLYDKIMDQQ RLEPEFFRVG 1320
FYGKKFPFFL RNKEFVCRGH DYERLEAFQQ RMLNEFPHAI AMQHANQPDE TIFQAEAQYL 1380
QIYAVTPIPE SQEVLQREGV PDNIKSFYKV NHIWKFRYDR PFHKGTKDKE NEFKSLWVER 1440
TSLYLVQSLP GISRWFEVEK REVVEMSPLE NAIEVLENKN QQLKTLISQC QTRQMQNINP 1500
LTMCLNGVID AAVNGGVSRY QEAFFVKEYI LSHPEDGEKI ARLRELMLEQ AQILEFGLAV 1560
HEKFVPQDMR PLHKKLVDQF FVMKSSLGIQ EFSACMQASP VHFPNGSPRV CRNSAPASVS 1620
PDGTRVIPRR SPLSYPAVNR YSSSSLSSQA SAEVSNITGQ SESSDEVFNM QPSPSTSSLS 1680
STHSASPNVT SSAPSSARAS PLLSDKHKHS RENSCLSPRE RPCSAIYPTP VEPSQRMLFN 1740
HIGDGALPRS DPNLSAPEKA VNPTPSSWSL DSGKEAKNMS DSGKLISPPV PPRPTQTASP 1800
ARHTTSVSPS PAGRSPLKGS VQSFTPSPVE YHSPGLISNS PVLSGSYSSG ISSLSRCSTS 1860
ETSGFENQVN EQSAPLPVPV PVPVPSYGGE EPVRKESKTP PPYSVYERTL RRPVPLPHSL 1920
SIPVTSEPPA LPPKPLAARS SHLENGARRT DPGPRPRPLP RKVSQL 1966 |
Gene Ontology | GO:0005829; C:cytosol; IDA:UniProtKB. GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IDA:UniProtKB. GO:0032420; C:stereocilium; ISS:HGNC. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0030675; F:Rac GTPase activator activity; IDA:HGNC. GO:0048365; F:Rac GTPase binding; IDA:HGNC. GO:0060326; P:cell chemotaxis; IMP:UniProtKB. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |