CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000640
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanidinoacetate N-methyltransferase 
Protein Synonyms/Alias
  
Gene Name
 Gamt 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
39THLQILGKPVMERWEubiquitination[1]
197WGELMKSKYTDITTMubiquitination[1]
251MITPLVTKH******ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 DOMAIN 13 236 RMT2.
 REGION 69 74 S-adenosyl-L-methionine binding (By
 REGION 90 92 S-adenosyl-L-methionine (By similarity).
 REGION 117 118 S-adenosyl-L-methionine binding (By
 REGION 171 172 Substrate binding (By similarity).
 BINDING 20 20 S-adenosyl-L-methionine (By similarity).
 BINDING 42 42 Substrate (By similarity).
 BINDING 46 46 Substrate (By similarity).
 BINDING 50 50 S-adenosyl-L-methionine (By similarity).
 BINDING 135 135 S-adenosyl-L-methionine and substrate (By  
Keyword
 Alternative splicing; Cell projection; Complete proteome; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 236 AA 
Protein Sequence
MSSSAASPLF APGEDCGPAW RAAPAAYDAS DTHLQILGKP VMERWETPYM HALAAAAASR 60
GGRVLEVGFG MAIAASRVQQ APIEEHWIIE CNDGVFQRLQ DWALRQPHKV VPLKGLWEEV 120
APTLPDGHFD GILYDTYPLS EEAWHTHQFN FIKLSSHGPT PSCPLASLQN HAFRLLKTGG 180
VLTYCNLTSW GELMKSKYTD ITTMFEETQV PALQEAGFLK ENICTEVMAL VPPADCRYYA 240
FPQMITPLVT KH 252 
Gene Ontology
 GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
 GO:0030731; F:guanidinoacetate N-methyltransferase activity; ISS:UniProtKB.
 GO:0006601; P:creatine biosynthetic process; IMP:MGI.
 GO:0009887; P:organ morphogenesis; IMP:MGI.
 GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
 GO:0007283; P:spermatogenesis; IMP:MGI. 
Interpro
 IPR016550; GuanidinoAc_N-MeTrfase.
 IPR026480; RMT2_dom. 
Pfam
  
SMART
  
PROSITE
 PS51559; SAM_RMT2 
PRINTS