UniProt Accession

 TREX1_HUMAN; Q9NSU2; B2RCN9; Q8TEU2; Q9BPW1; Q9Y4X2 

Genbank Protein ID

 AJ243797; AF319566; AF319567; AF319568; AF319569; AF151105; AK315196; AL137745; AF483777; BC023630 

Genbank Nucleotide ID

 CAB50866.1; AAK07613.1; AAK07614.1; AAK07615.1; AAK07616.1; AAD48774.2; BAG37636.1; AAL82504.1; AAH23630.1 

Protein Name

 Three prime repair exonuclease 1 

Protein Synonyms/Alias

 3'-5' exonuclease TREX1; DNase III 

Gene Name

 TREX1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
230	PSEHGPRKSYSLGSI	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair. 

Sequence Annotation

 REGION 75 76 Substrate binding (By similarity).
 REGION 109 118 Proline-rich region (By similarity).
 REGION 336 369 Necessary for cytoplasmic retention (By
 ACT_SITE 250 250 Proton donor/acceptor (By similarity).
 METAL 73 73 Magnesium 1 (By similarity).
 METAL 73 73 Magnesium 2 (By similarity).
 METAL 75 75 Magnesium 1 (By similarity).
 METAL 255 255 Magnesium 1 (By similarity).
 BINDING 184 184 Substrate (By similarity).
 BINDING 255 255 Substrate (By similarity).
 MOD_RES 133 133 Phosphoserine.
 MOD_RES 316 316 Phosphoserine.  

Keyword

 Aicardi-Goutieres syndrome; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; DNA damage; DNA repair; Exonuclease; Hydrolase; Magnesium; Metal-binding; Neurodegeneration; Nuclease; Nucleus; Phosphoprotein; Reference proteome; Systemic lupus erythematosus. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0005635; C:nuclear envelope; NAS:UniProtKB.
 GO:0008296; F:3'-5'-exodeoxyribonuclease activity; TAS:ProtInc.
 GO:0032558; F:adenyl deoxyribonucleotide binding; IEA:Compara.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0008853; F:exodeoxyribonuclease III activity; IEA:EC.
 GO:0046872; F:metal ion binding; NAS:UniProtKB.
 GO:0032405; F:MutLalpha complex binding; IDA:MGI.
 GO:0032407; F:MutSalpha complex binding; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; NAS:UniProtKB.
 GO:0003697; F:single-stranded DNA binding; TAS:UniProtKB.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0035458; P:cellular response to interferon-beta; IEA:Compara.
 GO:0006310; P:DNA recombination; NAS:UniProtKB.
 GO:0006260; P:DNA replication; NAS:UniProtKB.
 GO:0006298; P:mismatch repair; NAS:UniProtKB. 

Interpro

 IPR012337; RNaseH-like_dom. 

Pfam

  

SMART

  

PROSITE

  

PRINTS