| Tag | Content |
|---|
| CPLM ID | CPLM-012185 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrin alpha-7 |
Protein Synonyms/Alias | Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form |
Gene Name | ITGA7 |
Gene Synonyms/Alias | UNQ406/PRO768 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1126 | VPQYHAVKIPREDRQ | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. |
Sequence Annotation | REPEAT 35 103 FG-GAP 1.
REPEAT 110 175 FG-GAP 2.
REPEAT 185 238 FG-GAP 3.
REPEAT 292 350 FG-GAP 4.
REPEAT 351 411 FG-GAP 5.
REPEAT 412 467 FG-GAP 6.
REPEAT 471 530 FG-GAP 7.
REPEAT 1157 1160 1.
REPEAT 1165 1168 2.
REPEAT 1173 1176 3.
REGION 1157 1176 3 X 4 AA repeats of D-X-H-P.
MOTIF 1107 1111 GFFKR motif.
CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
CARBOHYD 786 786 N-linked (GlcNAc...) (Potential).
CARBOHYD 989 989 N-linked (GlcNAc...) (Potential).
CARBOHYD 1025 1025 N-linked (GlcNAc...).
CARBOHYD 1045 1045 N-linked (GlcNAc...) (Potential).
DISULFID 94 103 By similarity.
DISULFID 140 163 By similarity.
DISULFID 184 197 By similarity.
DISULFID 539 546 By similarity.
DISULFID 552 615 By similarity.
DISULFID 681 687 By similarity.
DISULFID 781 792 By similarity.
DISULFID 939 994 Interchain (between heavy and light
DISULFID 1001 1006 By similarity. |
Keyword | ADP-ribosylation; Alternative splicing; Calcium; Cell adhesion; Cell shape; Cleavage on pair of basic residues; Complete proteome; Congenital muscular dystrophy; Direct protein sequencing; Disulfide bond; Glycoprotein; Integrin; Membrane; Metal-binding; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1181 AA |
Protein Sequence | MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR 60
QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE 120
NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE 180
WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH 240
LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD 300
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL 360
TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS 420
PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI 480
KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA 540
GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ 600
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP 660
ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT RVSDTEFQPL PMDVDGTTAL 720
FALSGQPVIG LELMVTNLPS DPAQPQADGD DAHEAQLLVM LPDSLHYSGV RALDPAEKPL 780
CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS 840
ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL 900
GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV DSRDRRRREL 960
EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN CVVFSCPLYS FDRAAVLHVW 1020
GRLWNSTFLE EYSAVKSLEV IVRANITVKS SIKNLMLRDA STVIPVMVYL DPMAVVAEGV 1080
PWWVILLAVL AGLLVLALLV LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT 1140
GTILRNNWGS PRREGPDAHP ILAADGHPEL GPDGHPGPGT A 1181 |
Gene Ontology | GO:0009986; C:cell surface; IEA:Compara. GO:0005737; C:cytoplasm; IEA:Compara. GO:0008305; C:integrin complex; IEA:Compara. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0048514; P:blood vessel morphogenesis; IEA:Compara. GO:0016477; P:cell migration; IEA:Compara. GO:0007160; P:cell-matrix adhesion; TAS:ProtInc. GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW. GO:0007517; P:muscle organ development; TAS:ProtInc. GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. GO:0007519; P:skeletal muscle tissue development; IEA:Compara. |
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