UniProt Accession

 PRKX_HUMAN; P51817 

Genbank Protein ID

 X85545; BC041073 

Genbank Nucleotide ID

 CAA59733.1; AAH41073.1 

Protein Name

 cAMP-dependent protein kinase catalytic subunit PRKX 

Protein Synonyms/Alias

 PrKX; Protein kinase X; Protein kinase X-linked; Serine/threonine-protein kinase PRKX; Protein kinase PKX1 

Gene Name

 PRKX 

Gene Synonyms/Alias

 PKX1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
195	LTDFGFAKKLVDRTW	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. 

Sequence Annotation

 DOMAIN 49 303 Protein kinase.
 DOMAIN 304 358 AGC-kinase C-terminal.
 NP_BIND 55 63 ATP (By similarity).
 ACT_SITE 172 172 Proton acceptor (By similarity).
 BINDING 78 78 ATP (By similarity).  

Keyword

 Angiogenesis; ATP-binding; cAMP; Chromosomal rearrangement; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 358 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004691; F:cAMP-dependent protein kinase activity; IDA:UniProtKB.
 GO:0001525; P:angiogenesis; IMP:UniProtKB.
 GO:0031589; P:cell-substrate adhesion; IMP:UniProtKB.
 GO:0043542; P:endothelial cell migration; IMP:UniProtKB.
 GO:0001935; P:endothelial cell proliferation; IMP:UniProtKB.
 GO:0060562; P:epithelial tube morphogenesis; IDA:UniProtKB.
 GO:0060993; P:kidney morphogenesis; IDA:UniProtKB.
 GO:0030099; P:myeloid cell differentiation; IDA:UniProtKB.
 GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
 GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
 GO:0030155; P:regulation of cell adhesion; IDA:UniProtKB.
 GO:0030334; P:regulation of cell migration; IDA:UniProtKB.
 GO:2000696; P:regulation of epithelial cell differentiation involved in kidney development; IDA:UniProtKB. 

Interpro

 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00133; S_TK_X
 SM00220; S_TKc 

PROSITE

 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS