CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013633
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial 
Protein Synonyms/Alias
 Ubiquinone biosynthesis methyltransferase COQ5 
Gene Name
 COQ5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
95LGIHRVWKDLLLWKMubiquitination[1, 2]
153LSWEEIAKEYQNEEDubiquitination[3]
174VVVCDINKEMLKVGKubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Methyltransferase; Mitochondrion; Polymorphism; Reference proteome; Transferase; Transit peptide; Ubiquinone biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 327 AA 
Protein Sequence
MAAPGSCALW SYCGRGWSRA MRGCQLLGLR SSWPGDLLSA RLLSQEKRAA ETHFGFETVS 60
EEEKGGKVYQ VFESVAKKYD VMNDMMSLGI HRVWKDLLLW KMHPLPGTQL LDVAGGTGDI 120
AFRFLNYVQS QHQRKQKRQL RAQQNLSWEE IAKEYQNEED SLGGSRVVVC DINKEMLKVG 180
KQKALAQGYR AGLAWVLGDA EELPFDDDKF DIYTIAFGIR NVTHIDQALQ EAHRVLKPGG 240
RFLCLEFSQV NNPLISRLYD LYSFQVIPVL GEVIAGDWKS YQYLVESIRR FPSQEEFKDM 300
IEDAGFHKVT YESLTSGIVA IHSGFKL 327 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0006744; P:ubiquinone biosynthetic process; TAS:Reactome. 
Interpro
 IPR004033; UbiE/COQ5_MeTrFase.
 IPR023576; UbiE/COQ5_MeTrFase_CS.
 IPR025765; UbiE/COQ5_MeTrFase_dom. 
Pfam
 PF01209; Ubie_methyltran 
SMART
  
PROSITE
 PS01183; UBIE_1
 PS01184; UBIE_2 
PRINTS