CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038823
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sodium channel protein type 8 subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 Scn8a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
355KAMLEQLKKQQEEAQubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1903 AA 
Protein Sequence
PKYLSTKTFV VLNRGKTLFR FSATPALYIL SPFNLIRRIA IKILIHSFFS MIIMCTILTN 60
CVFMTFSNPP EWSKNVEYTF TGIYTFESLV KIIARGFCID GFTFLRDPWN WLDFSVIMMA 120
YVTEFVDLGN VSALRTFRVL RALKTISVIP GLKTIVGALI QSVKKLSDVM ILTVFCLSVF 180
ALIGLQLFMG NLRNKCVVWP INFNESYLEN GTRGFDWEEY INNKTNFYMV PGMLEPLLCG 240
NSSDAGQCPE GFQCMKAGRN PNYGYTSFDT FSWAFLALFR LMTQDYWENL YQLTLRAAGK 300
TYMIFFVLVI FVGSFYLVNL ILAVVAMAYE EQNQATLEEA EQKEAEFKAM LEQLKKQQEE 360
AQAAAMATSA GTVSEDAIEE EGEDGVGSPR SSSELSKLSS KSAKERRNRR KKRKQKELSE 420
GEEKGDPEKV FKSESEDGMR RKAFRLPDNR IGRKFSIMNQ SLLSIPGSPF LSRHNSKSSI 480
FSFRGPGRFR DPGSENEFAD DEHSTVEESE GRRDSLFIPI RARERRSSYS GYSGYSQCSR 540
SSRIFPSLRR SVKRNSTVDC NGVVSLIGPG SHIGRLLPEV KIDKAATDSA TTEVEIKKKG 600
PGSLLVSMDQ LASYGRKDRI NSIMSVVTNT LVEELEESQR KCPPCWYKFA NTFLIWECHP 660
YWIKLKEIVN LIVMDPFVDL AITICIVLNT LFMAMEHHPM TPQFEHVLAV GNLVFTGIFT 720
AEMFLKLIAM DPYYYFQEGW NIFDGFIVSL SLMELSLADV EGLSVLRSFR LLRVFKLAKS 780
WPTLNMLIKI IGNSVGALGN LTLVLAIIVF IFAVVGMQLF GKSYKECVCK INQECKLPRW 840
HMNDFFHSFL IVFRVLCGEW IETMWDCMEV AGQAMCLIVF MMVMVIGNLV VLNLFLALLL 900
SSFSADNLAA TDDDGEMNNL QISVIRIKKG VAWTKVKVHA FMQAHFKQRE ADEVKPLDEL 960
YEKKANCIAN HTGVDIHRNG DFQKNGNGTT SGIGSSVEKY IIDEDHMSFI NNPNLTVRVP 1020
IAVGESDFEN LNTEDVSSES DPEGSKDKLD DTSSSEGSTI DIKPEVEEVP VEQPEEYLDP 1080
DACFTEGCVQ RFKCCQVNIE EGLGKSWWIL RKTCFLIVEH NWFETFIIFM ILLSSGALAF 1140
EDIYIEQRKT IRTILEYADK VFTYIFILEM LLKWTAYGFV KFFTNAWCWL DFLIVAVSLV 1200
SLIANALGYS ELGAIKSLRT LRALRPLRAL SRFEGMRVVV NALVGAIPSI MNVLLVCLIF 1260
WLIFSIMGVN LFAGKYHYCF NETSEIRFEI DIVNNKTDCE KLMEGNSTEI RWKNVKINFD 1320
NVGAGYLALL QVATFKGWMD IMYAAVDSRK PDEQPDYEGN IYMYIYFVIF IIFGSFFTLN 1380
LFIGVIIDNF NQQKKKFGGQ DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP LNKIQGIVFD 1440
FVTQQAFDIV IMMLICLNMV TMMVETDTQS KQMENILYWI NLVFVIFFTC ECVLKMFALR 1500
HYYFTIGWNI FDFVVVILSI VGMFLADIIE KYFVSPTLFR VIRLARIGRI LRLIKGAKGI 1560
RTLLFALMMS LPALFNIGLL LFLVMFIFSI FGMSNFAYVK HEAGIDDMFN FETFGNSMIC 1620
LFQITTSAGW DGLLLPILNR PPDCSLDKEH PGSGFKGDCG NPSVGIFFFV SYIIISFLIV 1680
VNMYIAIILE NFSVATEESA DPLSEDDFET FYEIWEKFDP DATQFIEYCK LADFADALEH 1740
PLRVPKPNTI ELIAMDLPMV SGDRIHCLDI LFAFTKRVLG DSGELDILRQ QMEERFVASN 1800
PSKVSYEPIT TTLRRKQEEV SAVVLQRAYR GHLARRGFIC RKMASNKLEN GGTHRDKKES 1860
TPSTASLPSY DSVTKPDKEK QQRAEEGRRE RAKRQKEVRE SKC 1903 
Gene Ontology
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
 GO:0005248; F:voltage-gated sodium channel activity; IEA:Compara.
 GO:0007628; P:adult walking behavior; IEA:Compara.
 GO:0007517; P:muscle organ development; IEA:Compara.
 GO:0050905; P:neuromuscular process; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. 
Interpro
 IPR024583; DUF3451.
 IPR005821; Ion_trans_dom.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027359; K_channel_four-helix_dom.
 IPR008054; Na_channel_a8su.
 IPR001696; Na_channel_asu.
 IPR010526; Na_trans_assoc. 
Pfam
 PF11933; DUF3451
 PF00520; Ion_trans
 PF00612; IQ
 PF06512; Na_trans_assoc 
SMART
 SM00015; IQ 
PROSITE
 PS50096; IQ 
PRINTS
 PR00170; NACHANNEL.
 PR01667; NACHANNEL8.