CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018761
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Endothelial cell-selective adhesion molecule 
Protein Synonyms/Alias
  
Gene Name
 Esam 
Gene Synonyms/Alias
 Esam1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
279LLYQRRSKTLEELANubiquitination[1]
289EELANDIKEDAIAPRubiquitination[1]
302PRTLPWTKGSDTISKubiquitination[1]
309KGSDTISKNGTLSSVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Can mediate aggregation most likely through a homophilic molecular interaction. 
Sequence Annotation
 DOMAIN 37 146 Ig-like V-type.
 DOMAIN 159 243 Ig-like C2-type.
 CARBOHYD 111 111 N-linked (GlcNAc...) (Potential).
 CARBOHYD 172 172 N-linked (GlcNAc...) (Potential).
 CARBOHYD 216 216 N-linked (GlcNAc...) (Potential).
 CARBOHYD 239 239 N-linked (GlcNAc...) (Potential).
 DISULFID 177 227 By similarity.  
Keyword
 Cell adhesion; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal; Tight junction; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 394 AA 
Protein Sequence
MILQAGTPET SLLRVLFLGL STLAAFSRAQ MELHVPPGLN KLEAVEGEEV VLPAWYTMAR 60
EESWSHPREV PILIWFLEQE GKEPNQVLSY INGVMTNKPG TALVHSISSR NVSLRLGALQ 120
EGDSGTYRCS VNVQNDEGKS IGHSIKSIEL KVLVPPAPPS CSLQGVPYVG TNVTLNCKSP 180
RSKPTAQYQW ERLAPSSQVF FGPALDAVRG SLKLTNLSIA MSGVYVCKAQ NRVGFAKCNV 240
TLDVMTGSKA AVVAGAVVGT FVGLVLIAGL VLLYQRRSKT LEELANDIKE DAIAPRTLPW 300
TKGSDTISKN GTLSSVTSAR ALRPPKAAPP RPGTFTPTPS VSSQALSSPR LPRVDEPPPQ 360
AVSLTPGGVS SSALSRMGAV PVMVPAQSQA GSLV 394 
Gene Ontology
 GO:0005912; C:adherens junction; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005923; C:tight junction; IDA:MGI.
 GO:0016338; P:calcium-independent cell-cell adhesion; TAS:MGI.
 GO:0007156; P:homophilic cell adhesion; IDA:MGI. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set. 
Pfam
 PF07686; V-set 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS