| Tag | Content |
|---|
| CPLM ID | CPLM-019890 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein unc-45 homolog A |
Protein Synonyms/Alias | Unc-45A; Stromal membrane-associated protein 1; SMAP-1 |
Gene Name | Unc45a |
Gene Synonyms/Alias | Smap1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 707 | GTDVGQTKAAQALAK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen. |
Sequence Annotation | REPEAT 21 54 TPR 1.
REPEAT 58 91 TPR 2.
REPEAT 92 125 TPR 3.
MOD_RES 70 70 N6-acetyllysine (By similarity).
MOD_RES 483 483 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Chaperone; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Myogenesis; Nucleus; Reference proteome; Repeat; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 944 AA |
Protein Sequence | MTVSGPETPE PRPSDPGASS AEQLRKEGNE LFKCGDYEGA LTAYTQALSL GATPQDQAIL 60
HRNRAACHLK LEDYSKAESE ASKAIEKDGG DVKALYRRSQ ALEKLGRLDQ AVLDLKRCVS 120
LEPKNKVFQE SLRNIGGQIQ EKVRYMSSTD AKVEQMFQIL LDPKEKGTEK KQKASQNLVV 180
LAREDAGAEK IFRSNGVQLL QRLLDTEETD LMLAALRTLV GICSEHQSRT VATLSVLGTR 240
RVVSILGVEN QAVSLAACHL LQVIFDALKE GVKKGFRGKE GAIIVDPARE LKVLINSLLE 300
LLTEVGVSGQ GRDNALTLLI KMVPRKSPKD PNNSLTLWVI DQGLKKILEV GGSLQDAAGE 360
LTVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCENYIR NWFEGHGLAG KLRAIQTVSC 420
LLQGPCDAGN RALELSGVME SVIALCASER EEEQLVAVEA LIHAAGKAKR ASFITANGVS 480
LLKDLYKGSE RDSIRIRALV GLCKLGSAGG TDFSMKQFAE GSTLKLAKQC RKWLCNDQID 540
AGTRRWAVEG LAYLTFDADV KEEFVEDEAA LKALFQLSRS EERSVLFAVG SALVNCTNSY 600
DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVRARVKKLL AAGVVSAMTC MVKTESPVLT 660
NSCRELLSRV FLALVEEVED RGTVVAQGGG KALLPLALEG TDVGQTKAAQ ALAKLTITSN 720
PEMTFPGERI YEVVRPLVSL LHLSCSGLQN FEALMALTNL AGISERLRQK ILKEKAVPMI 780
EGYMFEEHEM IRRAATECMC NLAMSKEVQD LFEAQGNDRL KLLVLYSGED DELLRRAAAG 840
GLAMLTSMRP ALCSRIPQVT THWLEILQAL LLSPNQELQH RGTVVVLNMM QSSKEIAGTL 900
MESEVLEILS VLAKGEESPV TRAAAACLEK AVEYRLIQPN QDGE 944 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0051879; F:Hsp90 protein binding; IDA:MGI. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0061077; P:chaperone-mediated protein folding; IDA:MGI. GO:0007517; P:muscle organ development; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |