CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012382
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Major facilitator superfamily domain-containing protein 10 
Protein Synonyms/Alias
 Tetracycline transporter-like protein 
Gene Name
 MFSD10 
Gene Synonyms/Alias
 TETRAN 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
81AIGMPVEKRYNSVLFubiquitination[1]
154RLIGGISKGNVSLSTubiquitination[1]
340GGEVAAVKRALLLLVubiquitination[1]
453SYPAQTLKAE*****ubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump. 
Sequence Annotation
  
Keyword
 Apoptosis; Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 455 AA 
Protein Sequence
MGWGGGGGCT PRPPIHQQPP ERRVVTVVFL GLLLDLLAFT LLLPLLPGLL ESHGRAHDPL 60
YGSWQGGVDW FATAIGMPVE KRYNSVLFGG LIGSAFSVLQ FLCAPLTGAT SDCLGRRPVM 120
LLCLMGVATS YAVWATSRSF AAFLASRLIG GISKGNVSLS TAIVADLGSP LARSQGMAVI 180
GVAFSLGFTL GPMLGASLPL EMAPWFALLF AASDLLFIFC FLPETLPLEK RAPSIALGFR 240
DAADLLSPLA LLRFSAVARG QDPPSGDRLS SLRRLGLVYF LYLFLFSGLE YTLSFLTHQR 300
FQFSSLQQGK MFFLIGLTMA TIQGAYARRI HPGGEVAAVK RALLLLVPAF LLIGWGRSLP 360
VLGLGLLLYS FAAAVVVPCL SSVVAGYGSP GQKGTVMGTL RSLGALARAA GPLVAASVYW 420
LAGAQACFTT WSGLFLLPFF LLQKLSYPAQ TLKAE 455 
Gene Ontology
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0008493; F:tetracycline transporter activity; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 
Interpro
 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS