CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037299
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Receptor-type tyrosine-protein phosphatase C 
Protein Synonyms/Alias
  
Gene Name
 PTPRC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
266HDCTQVEKADTTICLubiquitination[1]
274ADTTICLKWKNIETFubiquitination[1]
276TTICLKWKNIETFTCubiquitination[1]
302GNMIFDNKEIKLENLubiquitination[1]
316LEPEHEYKCDSEILYubiquitination[1]
333HKFTNASKIIKTDFGubiquitination[1]
336TNASKIIKTDFGSPGubiquitination[1]
389KDCLNLDKNLIKYDLubiquitination[1]
492KNCDFRVKDLQYSTDubiquitination[1]
593DILLETYKRKIADEGubiquitination[1, 2]
616SIPRVFSKFPIKEARubiquitination[1, 2, 3, 4]
620VFSKFPIKEARKPFNubiquitination[1, 2]
667ASYIDGFKEPRKYIAubiquitination[1, 2, 4]
671DGFKEPRKYIAAQGPubiquitination[1]
711CEEGNRNKCAEYWPSubiquitination[1]
732AFGDVVVKINQHKRCubiquitination[1, 2]
752QKLNIVNKKEKATGRubiquitination[2]
753KLNIVNKKEKATGREubiquitination[1, 2]
783EDPHLLLKLRRRVNAubiquitination[1]
884PYLHNMKKRDPPSEPubiquitination[1, 2]
1015IVMLTELKHGDQEICacetylation[5]
1041GDIEVDLKDTDKSSTubiquitination[1]
1045VDLKDTDKSSTYTLRubiquitination[2]
1095ISMIQVVKQKLPQKNubiquitination[1]
1195KNNHQEDKIEFDNEVubiquitination[2]
1220NPLGAPEKLPEAKEQubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1256 AA 
Protein Sequence
MYLWLKLLAF GFAFLDTEVF VTGQSPTPSP TGLTTAKMPS VPLSSDPLPT HTTAFSPAST 60
FERENDFSET TTSLSPDNTS TQVSPDSLDN ASAFNTTGVS SVQTPHLPTH ADSQTPSAGT 120
DTQTFSGSAA NAKLNPTPGS NAISDAYLNA SETTTLSPSG SAVISTTTIA TTPSKPTCDE 180
KYANITVDYL YNKETKLFTA KLNVNENVEC GNNTCTNNEV HNLTECKNAS VSISHNSCTA 240
PDKTLILDVP PGVEKFQLHD CTQVEKADTT ICLKWKNIET FTCDTQNITY RFQCGNMIFD 300
NKEIKLENLE PEHEYKCDSE ILYNNHKFTN ASKIIKTDFG SPGEPQIIFC RSEAAHQGVI 360
TWNPPQRSFH NFTLCYIKET EKDCLNLDKN LIKYDLQNLK PYTKYVLSLH AYIIAKVQRN 420
GSAAMCHFTT KSAPPSQVWN MTVSMTSDNS MHVKCRPPRD RNGPHERYHL EVEAGNTLVR 480
NESHKNCDFR VKDLQYSTDY TFKAYFHNGD YPGEPFILHH STSYNSKALI AFLAFLIIVT 540
SIALLVVLYK IYDLHKKRSC NLDEQQELVE RDDEKQLMNV EPIHADILLE TYKRKIADEG 600
RLFLAEFQSI PRVFSKFPIK EARKPFNQNK NRYVDILPYD YNRVELSEIN GDAGSNYINA 660
SYIDGFKEPR KYIAAQGPRD ETVDDFWRMI WEQKATVIVM VTRCEEGNRN KCAEYWPSME 720
EGTRAFGDVV VKINQHKRCP DYIIQKLNIV NKKEKATGRE VTHIQFTSWP DHGVPEDPHL 780
LLKLRRRVNA FSNFFSGPIV VHCSAGVGRT GTYIGIDAML EGLEAENKVD VYGYVVKLRR 840
QRCLMVQVEA QYILIHQALV EYNQFGETEV NLSELHPYLH NMKKRDPPSE PSPLEAEFQR 900
LPSYRSWRTQ HIGNQEENKS KNRNSNVIPY DYNRVPLKHE LEMSKESEHD SDESSDDDSD 960
SEEPSKYINA SFIMSYWKPE VMIAAQGPLK ETIGDFWQMI FQRKVKVIVM LTELKHGDQE 1020
ICAQYWGEGK QTYGDIEVDL KDTDKSSTYT LRVFELRHSK RKDSRTVYQY QYTNWSVEQL 1080
PAEPKELISM IQVVKQKLPQ KNSSEGNKHH KSTPLLIHCR DGSQQTGIFC ALLNLLESAE 1140
TEEVVDIFQV VKALRKARPG MVSTFEQYQF LYDVIASTYP AQNGQVKKNN HQEDKIEFDN 1200
EVDKVKQDAN CVNPLGAPEK LPEAKEQAEG SEPTSGTEGP EHSVNGPASP ALNQGS 1256 
Gene Ontology
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC.
 GO:0050852; P:T cell receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR016335; Leukocyte_common_ag.
 IPR024739; PTP_recept_N.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF12567; CD45
 PF00041; fn3
 PF12453; PTP_N
 PF00102; Y_phosphatase 
SMART
 SM00060; FN3
 SM00194; PTPc 
PROSITE
 PS50853; FN3
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00700; PRTYPHPHTASE.