CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009745
UniProt Accession
Genbank Protein ID
 X15962 
Genbank Nucleotide ID
Protein Name
 40S ribosomal protein S12 
Protein Synonyms/Alias
  
Gene Name
 Rps12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
84IKVDDNKKLGEWVGLacetylation[1]
84IKVDDNKKLGEWVGLubiquitination[2]
93GEWVGLCKIDREGKPacetylation[1]
102DREGKPRKVVGCSCVacetylation[1]
112GCSCVVVKDYGKESQacetylation[1]
116VVVKDYGKESQAKDVacetylation[3]
116VVVKDYGKESQAKDVubiquitination[2]
121YGKESQAKDVIEEYFubiquitination[2]
129DVIEEYFKCKK****acetylation[1, 4]
129DVIEEYFKCKK****succinylation[4]
129DVIEEYFKCKK****ubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 132 AA 
Protein Sequence
MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC VLASNCDEPM 60
YVKLVEALLA EHQINLIKVD DNKKLGEWVG LCKIDREGKP RKVVGCSCVV VKDYGKESQA 120
KDVIEEYFKC KK 132 
Gene Ontology
 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
 IPR000530; Ribosomal_S12e. 
Pfam
 PF01248; Ribosomal_L7Ae 
SMART
  
PROSITE
 PS01189; RIBOSOMAL_S12E 
PRINTS
 PR00972; RIBSOMALS12E.