UniProt Accession

 ISOC2_HUMAN; Q96AB3; Q6ZN91; Q9H5G0 

Genbank Protein ID

 AK027122; AK131324; CR457377; CH471135; BC017344 

Genbank Nucleotide ID

 BAB15666.1; BAD18484.2; CAG33658.1; EAW72379.1; AAH17344.1 

Protein Name

 Isochorismatase domain-containing protein 2, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 ISOC2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
26	FLCDMQEKFRHNIAY	ubiquitination	[1, 2]
201	KEIQKLIKEPAPDSG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 MOD_RES 182 182 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Mitochondrion; Nucleus; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0031648; P:protein destabilization; IMP:BHF-UCL. 

Interpro

 IPR000868; Isochorismatase-like. 

Pfam

 PF00857; Isochorismatase 

SMART

  

PROSITE

  

PRINTS