| Tag | Content |
|---|
| CPLM ID | CPLM-010277 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-acetylmuramic acid 6-phosphate etherase |
Protein Synonyms/Alias | MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase |
Gene Name | murQ |
Gene Synonyms/Alias | yfeU; b2428; JW2421 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 233 | DVVATNEKLHVRQVN | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. |
Sequence Annotation | DOMAIN 55 218 SIS.
ACT_SITE 83 83 Proton donor (Probable).
ACT_SITE 114 114 Probable. |
Keyword | Carbohydrate metabolism; Complete proteome; Lyase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 298 AA |
Protein Sequence | MQFEKMITEG SNTASAEIDR VSTLEMCRII NDEDKTVPLA VERVLPDIAA AIDVIHAQVS 60
GGGRLIYLGA GTSGRLGILD ASECPPTYGV KPGLVVGLIA GGEYAIQHAV EGAEDSREGG 120
VNDLKNINLT AQDVVVGIAA SGRTPYVIAG LEYARQLGCR TVGISCNPGS AVSTTAEFAI 180
TPIVGAEVVT GSSRMKAGTA QKLVLNMLST GLMIKSGKVF GNLMVDVVAT NEKLHVRQVN 240
IVKNATGCSA EQAEAALIAC ERNCKTAIVM VLKNLDAAEA KKRLDQHGGF IRQVLDKE 298 |
Gene Ontology | GO:0030246; F:carbohydrate binding; IEA:InterPro. GO:0016835; F:carbon-oxygen lyase activity; IDA:EcoCyc. GO:0016803; F:ether hydrolase activity; IDA:EcoliWiki. GO:0097175; P:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process; IEA:UniProtKB-UniPathway. GO:0046348; P:amino sugar catabolic process; IMP:EcoCyc. GO:0005975; P:carbohydrate metabolic process; IEA:HAMAP. GO:0097173; P:N-acetylmuramic acid catabolic process; IEA:UniProtKB-UniPathway. GO:0009254; P:peptidoglycan turnover; IMP:EcoCyc. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |