| Tag | Content |
|---|
| CPLM ID | CPLM-020941 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-aminoadipic semialdehyde dehydrogenase |
Protein Synonyms/Alias | Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase |
Gene Name | Aldh7a1 |
Gene Synonyms/Alias | Ald7a1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 58 | RVRQASLKDYEETIG | acetylation | [1] | | 66 | DYEETIGKAKKAWNI | acetylation | [1] | | 96 | IGDAFREKIQLLGRL | acetylation | [1] | | 347 | LYGPLHTKQAVSMFV | acetylation | [1] | | 361 | VRAVEEAKKQGGTVV | acetylation | [1] | | 434 | LSSSIFTKDLGRIFR | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). |
Sequence Annotation | NP_BIND 274 279 NAD (By similarity).
ACT_SITE 296 296 Proton acceptor (By similarity).
ACT_SITE 330 330 Nucleophile (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Mitochondrion; NAD; Nucleus; Oxidoreductase; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 539 AA |
Protein Sequence | MSTLLIHHPQ YAWLQDLGLR EDNEGVYNGS WGGRGEVITT YCPANNEPIA RVRQASLKDY 60
EETIGKAKKA WNIWADIPAP KRGEIVRKIG DAFREKIQLL GRLVSLEMGK ILVEGIGEVQ 120
EYVDVCDYAA GLSRMIGGPT LPSERPGHAL IEMWNPLGLV GIITAFNFPV AVFGWNNAIA 180
LITGNVCLWK GAPTTSLVSV AVTKIIAQVL EDNLLPGAIC SLVCGGADIG TTMARDERVN 240
LLSFTGSTQV GKEVALMVQE RFGKSLLELG GNNAIIAFED ADLSLVVPSV LFAAVGTAGQ 300
RCTTVRRLFL HESIHNEVVD RLRSAYSQIR VGNPWDPNIL YGPLHTKQAV SMFVRAVEEA 360
KKQGGTVVYG GKVMDHPGNY VEPTIVTGLA HDAPIVHQET FAPILYVFKF QDEEEVFEWN 420
NEVKQGLSSS IFTKDLGRIF RWLGPKGSDC GIVNVNIPTS GAEIGGAFGG EKHTGGGRES 480
GSDAWKQYMR RSTCTINYST SLPLAQGIKF Q 511 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:MGI. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:EC. GO:0004043; F:L-aminoadipate-semialdehyde dehydrogenase activity; IEA:EC. GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |