| Tag | Content |
|---|
| CPLM ID | CPLM-010697 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Disks large-associated protein 2 |
Protein Synonyms/Alias | DAP-2; PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2; SAPAP2 |
Gene Name | Dlgap2 |
Gene Synonyms/Alias | Dap2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 703 | SSTRSIDKAVLVSKA | ubiquitination | [1] | | 709 | DKAVLVSKAEELLKS | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
Sequence Annotation | MOD_RES 228 228 Phosphoserine (By similarity).
MOD_RES 312 312 Phosphotyrosine (By similarity).
MOD_RES 440 440 Phosphoserine (By similarity).
MOD_RES 450 450 Phosphoserine (By similarity).
MOD_RES 453 453 Phosphoserine (By similarity).
MOD_RES 574 574 Phosphoserine (By similarity).
MOD_RES 745 745 Phosphoserine (By similarity).
MOD_RES 1012 1012 Phosphoserine (By similarity).
MOD_RES 1040 1040 Phosphoserine (By similarity).
MOD_RES 1047 1047 Phosphoserine (By similarity). |
Keyword | Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1059 AA |
Protein Sequence | MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEGGD LAQPGLSFPG PAEEDIDQQY 60
SWSPTQHFSE ERYSPAPRNM KGLTGSRNQP QLCVGHTCGL SPTDECEHPH DHVRHGPDVR 120
QPYLLSPAES CPMDHHRCSP RSSVHSECMM MPVMLGDHVS SSTFPRMHYS SHYDTRDDCA 180
TSHASTKVNR IPANLLDQFE KQLPLHRDGF HTLQYHRASA ATEQRNESPG RIRHLVHSVQ 240
KLFTKSHSLE GSSKSNINGT KSEGRMDDHH QSHLSKHSKR SKSKERKPES KHKSGMSSWW 300
SSDDNLDSDS TYRTPSVAHR HHMDHIPHCY PEALQSPFGD LSLKTSKSNS DVKCSACEGL 360
ALTPDTRYMK RSSWSTLTVS QAKEAYRKSS LNLDKPLVHP EIKPSLQPCH YLQVPQDDWG 420
AYPTGGKEEE IPCRRMRSGS YIKAMGDEES GESDSSPKTS PTVALRPEPL LKSIIQRPLG 480
DHQTQSYLQA ATEVPVGHSL DPSVNYNSPK FRSRNQSYMR AVSTLSQASC VSQMSEAEVN 540
GQFESVCESV FSEVESQAMD ALDLPGCFRT RSHSYLRAIQ AGYSQDDECI PVMTPSNMTS 600
TIRSTAAVSY TNYKKTPPPV PPRTTSKPLI SVTAQSSTES TQDAYQDSRA QRMSPWPQDS 660
RGGLYNSMDS LDSNKAMNLA LESAAAQRHA ADTQSSSTRS IDKAVLVSKA EELLKSRCSS 720
IGVQDSEFPD HQPYPRSDVE TATDSDTESR GLREYHSVGV QVEDEKRHGR FKRSNSVTAA 780
VQADLELEGF PGHVSMEDKG LQFGSSFQRH SEPSTPTQYG ALRTVRTQGL FSYREDYRTQ 840
VDTSTLPPPD PWLEPSLDTV ETGRMSPCRR DGSWFLKLLH TETKKMEGWC KEMEREAEEN 900
DLSEEILGKI RSAVGSAQLL MSQKFQQFYW LCQQNMDPSA MPRPTSQDLA GYWDMLQLSV 960
EDVSMKFDEL HQLKLNDWKI MESPERKEER KIPPPIPKKP PKGKFPITRE KSLDLPDRQR 1020
QEARRRLMAA KRAASFRQNS ATERADSIEI YIPEAQTRL 1059 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0030425; C:dendrite; IDA:RGD. GO:0005883; C:neurofilament; NAS:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell. GO:0045211; C:postsynaptic membrane; NAS:RGD. GO:0004385; F:guanylate kinase activity; NAS:RGD. GO:0019904; F:protein domain specific binding; IDA:RGD. GO:0007270; P:neuron-neuron synaptic transmission; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |