UniProt Accession

 TFDP2_HUMAN; Q14188; B7Z8C8; B7Z8L5; D3DNG1; E9PFC3; F8WAI2; Q13331; Q14187; Q6R754; Q8WU88; Q9UG28 

Genbank Protein ID

 L40386; U18422; AY509596; AK303181; AK303634; CR597951; AC108679; AC112504; AC128648; AC133435; CH471052; CH471052; BC021113; U75488; AL080206; U35117 

Genbank Nucleotide ID

 AAA69016.1; AAB60378.1; AAR89905.1; BAH13914.1; BAH14001.1; EAW78977.1; EAW78981.1; AAH21113.1; AAB37321.1; CAB45775.2; AAC50642.1 

Protein Name

 Transcription factor Dp-2 

Protein Synonyms/Alias

 E2F dimerization partner 2 

Gene Name

 TFDP2 

Gene Synonyms/Alias

 DP2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
110	GDRKRARKFIDSDFS	ubiquitination	[1]
120	DSDFSESKRSKKGDK	ubiquitination	[1]
138	GLRHFSMKVCEKVQR	ubiquitination	[1]
178	ADSAYDQKNIRRRVY	ubiquitination	[1]
201	MNIISKEKKEIKWIG	ubiquitination	[1]
202	NIISKEKKEIKWIGL	ubiquitination	[1]
205	SKEKKEIKWIGLPTN	ubiquitination	[1]
224	CQNLEIEKQRRIERI	ubiquitination	[1]
249	LLQQIAFKNLVQRNR	ubiquitination	[1, 2, 3]
328	SFGLESGKCSLEDLK	ubiquitination	[1]
335	KCSLEDLKLAKSLVP	ubiquitination	[1]
338	LEDLKLAKSLVPKAL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis. 

Sequence Annotation

 DNA_BIND 129 210 Potential.
 REGION 219 292 Dimerization (Potential).
 REGION 229 261 DCB1.
 REGION 274 330 DCB2.
 MOTIF 103 118 Nuclear localization signal (By
 MOTIF 176 210 DEF box.  

Keyword

 3D-structure; Activator; Alternative splicing; Cell cycle; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 446 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005667; C:transcription factor complex; IEA:InterPro.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:ProtInc.
 GO:0003712; F:transcription cofactor activity; TAS:ProtInc.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:Reactome.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR003316; E2F_TDP.
 IPR014889; Transc_factor_DP_C.
 IPR016556; Transcription_factor_DP_subgr.
 IPR015648; Transcrpt_fac_DP.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF08781; DP
 PF02319; E2F_TDP 

SMART

  

PROSITE

  

PRINTS