CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025155
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RAS-related C3 botulinum substrate 1, isoform CRA_a 
Protein Synonyms/Alias
 Ras-related C3 botulinum toxin substrate 1 
Gene Name
 Rac1 
Gene Synonyms/Alias
 mCG_23557 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
115SFENVRAKWYPEVRHubiquitination[1]
135PIILVGTKLDLRDDKubiquitination[1]
142KLDLRDDKDTIEKLKacetylation[2]
142KLDLRDDKDTIEKLKubiquitination[1]
147DDKDTIEKLKEKKLTubiquitination[1]
152IEKLKEKKLTPITYPubiquitination[1]
166PQGLAMAKEIGAVKYubiquitination[1]
172AKEIGAVKYLECSALubiquitination[1]
185ALTQRGLKTVFDEAIubiquitination[1]
202VLCPPPVKKRKRKCLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Membrane; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 211 AA 
Protein Sequence
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG 60
QEDYDRLRPL SYPQTVGDTC GKDRPSRGKD KPIADVFLIC FSLVSPASFE NVRAKWYPEV 120
RHHCPNTPII LVGTKLDLRD DKDTIEKLKE KKLTPITYPQ GLAMAKEIGA VKYLECSALT 180
QRGLKTVFDE AIRAVLCPPP VKKRKRKCLL L 211 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.
 GO:0019897; C:extrinsic to plasma membrane; IDA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0005525; F:GTP binding; IDA:MGI.
 GO:0003924; F:GTPase activity; IDA:MGI.
 GO:0048532; P:anatomical structure arrangement; IMP:MGI.
 GO:0002093; P:auditory receptor cell morphogenesis; IMP:MGI.
 GO:0007411; P:axon guidance; IMP:MGI.
 GO:0045216; P:cell-cell junction organization; IMP:MGI.
 GO:0021799; P:cerebral cortex radially oriented cell migration; IMP:MGI.
 GO:0090103; P:cochlea morphogenesis; IMP:MGI.
 GO:0007010; P:cytoskeleton organization; IDA:MGI.
 GO:0048813; P:dendrite morphogenesis; IGI:MGI.
 GO:0071542; P:dopaminergic neuron differentiation; IGI:MGI.
 GO:0021831; P:embryonic olfactory bulb interneuron precursor migration; IMP:MGI.
 GO:0006897; P:endocytosis; IDA:MGI.
 GO:0003382; P:epithelial cell morphogenesis; IMP:MGI.
 GO:0006972; P:hyperosmotic response; IDA:MGI.
 GO:0030032; P:lamellipodium assembly; IDA:MGI.
 GO:0030838; P:positive regulation of actin filament polymerization; IDA:MGI.
 GO:0010592; P:positive regulation of lamellipodium assembly; ISO:MGI.
 GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IMP:MGI.
 GO:0030334; P:regulation of cell migration; IMP:MGI.
 GO:0031529; P:ruffle organization; ISO:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI.
 GO:0034446; P:substrate adhesion-dependent cell spreading; IDA:MGI.
 GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway; IGI:MGI. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 
Pfam
 PF00071; Ras 
SMART
 SM00174; RHO 
PROSITE
 PS51420; RHO 
PRINTS
 PR00449; RASTRNSFRMNG.