UniProt Accession

 LPCT4_HUMAN; Q643R3; A8K2K8; O43412; Q7Z4P4; Q8IUL7; Q8TB38 

Genbank Protein ID

 AY734233; AF529233; AF542964; AK290273; CH471125; BC024892; BC092463; AF007155 

Genbank Nucleotide ID

 AAU34184.1; AAP97722.1; AAN33178.1; BAF82962.1; EAW92306.1; AAH24892.2; AAH92463.1; AAC19156.1 

Protein Name

 Lysophospholipid acyltransferase LPCAT4 

Protein Synonyms/Alias

 1-acylglycerol-3-phosphate O-acyltransferase 7; 1-AGP acyltransferase 7; 1-AGPAT 7; Acyltransferase-like 3; Lysophosphatidylcholine acyltransferase 4; Lysophosphatidylethanolamine acyltransferase 2; Plasmalogen synthase 

Gene Name

 LPCAT4 

Gene Synonyms/Alias

 AGPAT7; AYTL3; LPEAT2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
145	LLPCDLPKVVSRAEN	ubiquitination	[1]
216	KKALLKFKPGAFIAG	ubiquitination	[1]
319	VIVVGRLKVALEPQL	ubiquitination	[1]
331	PQLWELGKVLRKAGL	ubiquitination	[1]
335	ELGKVLRKAGLSAGY	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. 

Sequence Annotation

 MOTIF 129 134 HXXXXD motif.
 CARBOHYD 152 152 N-linked (GlcNAc...) (Potential).  

Keyword

 Acyltransferase; Complete proteome; Endoplasmic reticulum; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 524 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0050200; F:plasmalogen synthase activity; IEA:EC.
 GO:0006654; P:phosphatidic acid biosynthetic process; TAS:Reactome.
 GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome.
 GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; TAS:Reactome.
 GO:0036148; P:phosphatidylglycerol acyl-chain remodeling; TAS:Reactome.
 GO:0036150; P:phosphatidylserine acyl-chain remodeling; TAS:Reactome.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR002123; Plipid/glycerol_acylTrfase. 

Pfam

 PF01553; Acyltransferase 

SMART

 SM00563; PlsC 

PROSITE

  

PRINTS