UniProt Accession

 RD23A_MOUSE; P54726; B7ZNQ1 

Genbank Protein ID

 X92410; BC145372; CH466525 

Genbank Nucleotide ID

 CAA63145.1; AAI45373.1; EDL10960.1 

Protein Name

 UV excision repair protein RAD23 homolog A 

Protein Synonyms/Alias

 HR23A; mHR23A 

Gene Name

 Rad23a 

Gene Synonyms/Alias

 Mhr23a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
8	MAVTITLKTLQQQTF	ubiquitination	[1]
16	TLQQQTFKIRMEPDE	ubiquitination	[1]
26	MEPDETVKVLKEKIE	ubiquitination	[1]
36	KEKIEAEKGRDAFPV	ubiquitination	[1]
47	AFPVAGQKLIYAGKI	acetylation	[2, 3]
47	AFPVAGQKLIYAGKI	ubiquitination	[1]
53	QKLIYAGKILSDDVP	acetylation	[3]
53	QKLIYAGKILSDDVP	ubiquitination	[1]
62	LSDDVPIKEYHIDEK	ubiquitination	[1]
78	FVVVMVTKAKAGQGI	ubiquitination	[1]
80	VVMVTKAKAGQGIPA	ubiquitination	[1]
122	PPTSREDKSPSEEST	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). 

Sequence Annotation

 DOMAIN 1 79 Ubiquitin-like.
 DOMAIN 161 201 UBA 1.
 DOMAIN 318 358 UBA 2.
 MOD_RES 123 123 Phosphoserine.
 MOD_RES 133 133 Phosphoserine (By similarity).
 MOD_RES 205 205 Phosphoserine (By similarity).
 MOD_RES 295 295 Phosphoserine (By similarity).
 MOD_RES 357 357 Phosphoserine.
 CROSSLNK 122 122 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; DNA damage; DNA repair; Isopeptide bond; Nucleus; Phosphoprotein; Proteasome; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 363 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
 GO:0003684; F:damaged DNA binding; IEA:InterPro.
 GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
 GO:0006974; P:response to DNA damage stimulus; IGI:MGI. 

Interpro

 IPR004806; Rad23.
 IPR006636; STI1_HS-bd.
 IPR009060; UBA-like.
 IPR000449; UBA/transl_elong_EF1B_N.
 IPR015940; UBA/transl_elong_EF1B_N_euk.
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup.
 IPR015360; XPC-bd. 

Pfam

 PF00627; UBA
 PF00240; ubiquitin
 PF09280; XPC-binding 

SMART

 SM00727; STI1
 SM00165; UBA
 SM00213; UBQ 

PROSITE

 PS50030; UBA
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 

PRINTS

 PR01839; RAD23PROTEIN.