CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000163
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Microsomal triglyceride transfer protein large subunit 
Protein Synonyms/Alias
  
Gene Name
 Mttp 
Gene Synonyms/Alias
 Mtp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
199TYQAQQDKVVKIKALacetylation[1]
286GPRMIPGKQVAGVIKubiquitination[2]
293KQVAGVIKAVDSKYKacetylation[1]
478LILGGLEKPEKKEDTacetylation[1]
536SFITDEVKKTLNRIYacetylation[1]
624HNYDRFSKSGSSSAYubiquitination[2]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets. 
Sequence Annotation
 DOMAIN 28 658 Vitellogenin.  
Keyword
 Alternative promoter usage; Cholesterol metabolism; Complete proteome; Disulfide bond; Endoplasmic reticulum; Golgi apparatus; Lipid metabolism; Lipid-binding; Reference proteome; Signal; Steroid metabolism; Sterol metabolism; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 894 AA 
Protein Sequence
MTVVMGKCQV SDGRQLLLFY AVLLLFPTLC AMQNSGHTTG LSLNNERLYK LTYSTEVFLD 60
GGKGKPQDSV GYKISSDVDV VLLWRNPDGD DDQVIQVTIT AVNVENAGQQ RGEKSIFQGK 120
STPKIIGKDN LEALQRPMLL HLVRGKVKEF YSYENEPVGI ENLKRGLASL FQMQLSSGTT 180
NEVDISGDCK VTYQAQQDKV VKIKALDTCK IERSGFTTAN QVLGVSSKAT SVTTYKIEDS 240
FVTAVLAEET RAFALNFQQT IAGKIVSKQK LELKTTEAGP RMIPGKQVAG VIKAVDSKYK 300
AIPIVGQVLE RVCKGCPSLA EHWKSIRKNL EPENLSKAEA VQSFLAFIQH LRTSRREEIL 360
QILKAEKKEV LPQLVDAVTS AQTPDSLEAI LDFLDFKSDS SIILQERFLY ACGFATHPDE 420
ELLRALLSKF KGSFASNDIR ESVMIIIGAL VRKLCQNEGC KLKAVVEAKK LILGGLEKPE 480
KKEDTTMYLL ALKNALLPEG IPLLLKYAEA GEGPVSHLAT TVLQRYDVSF ITDEVKKTLN 540
RIYHQNRKVH EKTVRTTAAA VILKNPSYMD VKNILLSIGE LPKEMNKYML TVVQDILHFE 600
MPASKMIRRV LKEMAVHNYD RFSKSGSSSA YTGYVERSPR AASTYSLDIL YSGSGILRRS 660
NLNIFQYIGK AELHGSQVVI EAQGLEGLIA ATPDEGEENL DSYAGMSAIL FDVQLRPVTF 720
FNGYSDLMSK MLSASGDPVS VVKGLILLID HSQDIQLQSG LKANMEIQGG LAIDISGSME 780
FSLWYRESKT RVKNRVAVVI TSDVTVDASF VKAGVESRAE TEAGLEFIST VQFSQYPFLV 840
CMQMDKAEAP LRQFETKYER LSTGRGYVSR RRKESLVAGC ELPLHQENSE MCNVVFPPQP 900
ESDNSGGWF 909 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0031988; C:membrane-bounded vesicle; IEA:Compara.
 GO:0031528; C:microvillus membrane; IEA:Compara.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0005319; F:lipid transporter activity; IDA:MGI.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
 GO:0042953; P:lipoprotein transport; IDA:MGI.
 GO:0006497; P:protein lipidation; IDA:MGI.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IDA:MGI. 
Interpro
 IPR015819; Lipid_transp_b-sht_shell.
 IPR001747; Lipid_transpt_N.
 IPR015816; Vitellinogen_b-sht_N.
 IPR011030; Vitellinogen_superhlx. 
Pfam
 PF01347; Vitellogenin_N 
SMART
 SM00638; LPD_N 
PROSITE
 PS51211; VITELLOGENIN 
PRINTS