CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041205
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Gm20441 
Protein Synonyms/Alias
  
Gene Name
 Gm20441 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
249LEAWQIGKKGT****acetylation[1, 2, 3, 4]
249LEAWQIGKKGT****phosphoglycerylation[5]
249LEAWQIGKKGT****succinylation[4]
249LEAWQIGKKGT****ubiquitination[6]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 252 AA 
Protein Sequence
XLELYLDLMS QPCRAVYIFA KKNGIPFQLR TIELLKGQQY TDSFAQVNPL RKVPALKDGD 60
FVLAESVAIL LYLSRKYKAP DHWYPQDLQT RARVDEYLAW QHTALRSCCT RAMWQKMMFP 120
VFLGQPVPPE MLASTLAELD GCLQVLEDKF LRNQAFLTGS HISVADLVAI TELMHRVSVT 180
IRPGMTLLMN KSTEPCAHLL VSSIGVVGTA EQNRTHSASF FKFLTEELSL DQDRIVIRFF 240
PLEAWQIGKK GT 252 
Gene Ontology
  
Interpro
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR001398; Macrophage_inhib_fac.
 IPR019829; Macrophage_inhib_fac_CS.
 IPR014347; Tautomerase/MIF_sf.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF01187; MIF 
SMART
  
PROSITE
 PS50405; GST_CTER
 PS50404; GST_NTER
 PS01158; MIF 
PRINTS